Genetics of circadian rhythms and mood spectrum disorders
Genetics of circadian rhythms and mood spectrum disorders
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DOI：
10.1016/j.euroneuro.2011.07.007
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发表时间：
2011-09-01
影响因子：
5.6
通讯作者：
Leboyer, M.
中科院分区：
文献类型：
--
作者：
Etain, B.;Milhiet, V.;Leboyer, M.
情绪谱障碍（双相情感障碍、复发性抑郁障碍和季节性情感障碍）伴随着昼夜节律失调，这可能发生在急性情绪发作期间以及正常情绪期间，并且在双相情感障碍缓解期患者中特别常见。这表明改变的昼夜节律可能是这些疾病的生物标志物。节律功能障碍已被观察到在心境障碍患者通过使用活动测量和评估社会度量的节奏，昼夜偏好和褪黑激素分泌。由于这些标记中的许多是可遗传的，因此由时钟基因驱动，这些基因可能代表情绪谱系障碍的易感因素。事实上，一些遗传关联研究表明，某些昼夜节律基因变异在这些疾病的易感性中发挥作用。这种与昼夜节律基因（如CLOCK、ARNTL1、NPAS2、PER 3和NR1D1）的联系已在双相情感障碍中反复得到证实，在复发性抑郁症和季节性情感障碍中也有较低程度的证明。情绪谱系障碍的昼夜节律表型和昼夜节律基因的研究代表了一个主要的研究领域，可能揭示这些疾病的病理生理决定因素。(C)2011 Elsevier B.V.和ECNP。All rights reserved.
Mood spectrum disorders (bipolar disorder, recurrent depressive disorder and seasonal affective disorder) are accompanied by circadian deregulations, which can occur during acute mood episodes as well as during euthymic periods, and are particularly common among bipolar patients in remission. This suggests that altered circadian rhythms may be biological markers of these disorders. Rhythm dysfunctions have been observed in mood disorder patients by using actigraphic measures and by assessing social metric rhythms, diurnal preferences and melatonin secretion. Since many of these markers are heritable and therefore driven by clock genes, these genes may represent susceptibility factors for mood spectrum disorders. Indeed, several genetic association studies have suggested that certain circadian gene variants play a role in susceptibility to these disorders. Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders. The study of circadian phenotypes and circadian genes in mood spectrum disorders represents a major field of research that may yet reveal the pathophysiological determinants of these disorders. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.