Clinical utility of measuring expression levels of Stanniocalcin 2 in patients with colorectal cancer
Clinical utility of measuring expression levels of Stanniocalcin 2 in patients with colorectal cancer
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DOI：
10.1007/s12032-014-0237-8
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发表时间：
2014-10-01
期刊：
影响因子：
3.4
通讯作者：
Sakhinia, Ebrahim
中科院分区：
文献类型：
--
作者：
Hashemzadeh, Shahryar;Arabzadeh, Amir Ahmad;Sakhinia, Ebrahim
Stanniocalcin 2(STC2)是Stanniocalcin家族中的一个新成员，其功能尚不清楚。它在几种癌症中的表达具有临床意义。本研究的目的是评估STC2在结直肠癌(CRC)患者中表达水平的临床价值。手术中共获得47个肿瘤和匹配的无肿瘤边缘样本。采用实时荧光定量聚合酶链式反应检测肿瘤及边缘组织中STC2基因的表达水平。肿瘤组织中STC2基因的表达水平明显高于对照组。(r=0.36，p
Stanniocalcin 2 (STC2) is a novel member of the Stanniocalcin family, the function of which remains unclear. Its expression is clinically significant in several cancers. The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC) patients. A total of 47 tumor and matched tumor-free margin samples were obtained during surgery. The STC2 mRNA expression level in tumor and marginal tissue was examined by real-time quantitative PCR. STC2 mRNA expression levels were higher in tumor tissues than the control. (r = 0.36, p