Hemispheric asymmetry of visual scene processing in the human brain: evidence from repetition priming and intrinsic activity.
Hemispheric asymmetry of visual scene processing in the human brain: evidence from repetition priming and intrinsic activity.
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DOI：
10.1093/cercor/bhr273
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发表时间：
2012-08
期刊：
影响因子：
3.7
通讯作者：
W. Stevens;Itamar Kahn;G. Wig;D. Schacter
中科院分区：
文献类型：
--
作者：
W. Stevens;Itamar Kahn;G. Wig;D. Schacter
大脑半球认知过程的不对称专门化是大脑健康发展的标志，也是人类高级认知基础的重要进化特征。虽然以前的研究，包括启动、分裂视野呈现和分裂脑患者的研究，证明了特定形式的视觉加工与抽象形式的视觉加工的左右不对称的一般模式，但对这种分离背后的大脑组织知之甚少。在这里，我们使用复杂视觉场景的重复启动和高分辨率功能磁共振成像(MRI)，在已知对视觉空间场景的加工至关重要的区域(海马旁位置区[PPA])内，展示了左右半球视觉加工的不对称形式特异性。接下来，我们使用静息态功能连接性MRI分析来证明这种功能不对称分别与左右PPA与关键参与知觉与概念加工的区域的内在活动相关。我们的结果表明，PPA包括大脑半球的偏侧化亚区，这些亚区参与视觉场景分析的功能分离但互补的组成部分。此外，这种功能不对称与PPA的不同内在功能连接有关，PPA具有不同的大脑区域，这些区域介导可分离的认知过程。
Asymmetrical specialization of cognitive processes across the cerebral hemispheres is a hallmark of healthy brain development and an important evolutionary trait underlying higher cognition in humans. While previous research, including studies of priming, divided visual field presentation, and split-brain patients, demonstrates a general pattern of right/left asymmetry of form-specific versus form-abstract visual processing, little is known about brain organization underlying this dissociation. Here, using repetition priming of complex visual scenes and high-resolution functional magnetic resonance imaging (MRI), we demonstrate asymmetrical form specificity of visual processing between the right and left hemispheres within a region known to be critical for processing of visual spatial scenes (parahippocampal place area [PPA]). Next, we use resting-state functional connectivity MRI analyses to demonstrate that this functional asymmetry is associated with differential intrinsic activity correlations of the right versus left PPA with regions critically involved in perceptual versus conceptual processing, respectively. Our results demonstrate that the PPA comprises lateralized subregions across the cerebral hemispheres that are engaged in functionally dissociable yet complementary components of visual scene analysis. Furthermore, this functional asymmetry is associated with differential intrinsic functional connectivity of the PPA with distinct brain areas known to mediate dissociable cognitive processes.