Mechanisms of FGF gradient formation during embryogenesis.
Mechanisms of FGF gradient formation during embryogenesis.
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DOI：
10.1016/j.semcdb.2015.10.004
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发表时间：
2016-05
影响因子：
7.3
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Balasubramanian R;Zhang X
成纤维细胞生长因子（FGF）长期以来一直被认为影响胚胎发育的形态发生。FGF形态发生蛋白的信号传导通过在发育中的胚胎上产生浓度梯度来编码组织的位置同一性。在最近的过去，已经阐明了影响这种梯度发展的各种机制。FGF梯度形成的这些机制表现为FGF配体扩散的细胞外控制或FGF增殖和信号传导的亚细胞控制。在这篇综述中，我们描述了我们目前的理解，FGF作为一种形态，FGF梯度形成的硫酸乙酰肝素蛋白多糖（HSPGs）和FGF信号的影响梯度形成的细胞内调节机制的细胞外控制。
Fibroblast growth factors (FGFs) have long been attributed to influence morphogenesis in embryonic development. Signaling by FGF morphogen encodes positional identity of tissues by creating a concentration gradient over the developing embryo. Various mechanisms that influence the development of such gradient have been elucidated in the recent past. These mechanisms of FGF gradient formation present either as an extracellular control over FGF ligand diffusion or as a subcellular control of FGF propagation and signaling. In this review, we describe our current understanding of FGF as a morphogen, the extracellular control of FGF gradient formation by heparan sulfate proteoglycans (HSPGs) and mechanisms of intracellular regulation of FGF signaling that influence gradient formation.