Overexpression of Stathmin 1 correlates with poor prognosis and promotes cell migration and proliferation in oesophageal squamous cell carcinoma
Overexpression of Stathmin 1 correlates with poor prognosis and promotes cell migration and proliferation in oesophageal squamous cell carcinoma
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Stathmin 1 过度表达与食管鳞状细胞癌预后不良相关，并促进细胞迁移和增殖
DOI：
10.3892/or.2017.6039
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发表时间：
2017-12-01
期刊：
影响因子：
4.2
通讯作者：
Xu, Li-Yan
中科院分区：
文献类型：
--
作者：
Ni, Peng-Zhi;He, Jian-Zhong;Xu, Li-Yan
Stathmin 1(STMN1)是一种微管调节蛋白，在肿瘤细胞的增殖和迁移中发挥重要作用。在许多人类肿瘤中，STMN1的过度表达与临床病理特征有关。本研究旨在探讨STMN1在食道鳞状细胞癌(ESCC)中的表达及其与临床病理特征的关系及其生物学功能。采用免疫组织化学方法(IHC)检测276例食管癌组织标本中STMN1的水平，以评价STMN1对预后的影响。免疫组化结果显示，STMN1高表达患者的5年总生存期比低表达患者差(OS：21.2vs.53.7%，P
Stathmin 1 (STMN1) is a microtubule-regulated protein that plays an important role in tumour cell proliferation and migration. Overexpression of STMN1 is associated with clinicopathological characteristics in many human cancers. The aim of the present study was to investigate STMN1 expression, its correlation with clinicopathological characteristics, and its exact biological function in oesophageal squamous cell carcinoma (ESCC). STMN1 levels were measured in the ESCC tissue specimens of 276 patients by immunohistochemistry (IHC) to assess the prognostic efficacy of STMN1. IHC showed that patients with overexpression of STMN1 had a poorer prognosis compared with those with low expression, both in regards to 5-year overall survival (OS; 21.2 vs. 53.7%, P