Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.
Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity.
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网状细胞肉瘤：抗体依赖性细胞介导的免疫中的效应细胞。
作者：
P. Ralph;J. Prichard;M. Cohn
一种可移植的，鼠网状细胞肉瘤的描述，表现出细胞学，粘附和巨噬细胞的吞噬特性。在相应的抗血清存在下，它与红细胞形成特异性红细胞。腹水细胞介导抗体依赖性细胞免疫，通过51Cr标记红细胞释放放射性测定。通过在F1小鼠中生长肿瘤并通过抗H2血清和补体去除宿主细胞，排除了污染宿主细胞在细胞毒性反应中的作用。肿瘤细胞具有IgG2a和IgG2b免疫球蛋白的受体。免疫系统中效应细胞的纯群体的可用性允许研究根据外源细胞裂解的生化过程。
A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages. It forms specific rosettes with erythrocytes in the presence of the corresponding anti-serum. The ascites cells mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes. The contribution of contaminating host cells in the cytotoxic reaction was ruled out by growing the tumor in F1 mice and removing the host cells by anti-H2 serum and complement. The tumor cells have receptors for IgG2a and IgG2b immunoglobulins. The availability of a pure population of effector cells in the immune system allows study of the biochemical processes pursuant to lysis of foreign cells.