Rupture of the gallbladder in a patient with acquired factor VIII inhibitors and systemic lupus erythematosus.
Rupture of the gallbladder in a patient with acquired factor VIII inhibitors and systemic lupus erythematosus.
复制标题
患有获得性因子 VIII 抑制剂和系统性红斑狼疮患者胆囊破裂。
DOI：
10.2169/internalmedicine.43.1073
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发表时间：
2004
影响因子：
1.2
通讯作者：
S. Fujita
中科院分区：
文献类型：
--
作者：
S. Onishi;N. Hōjō;I. Sakai;M. Yasukawa;T. Hato;Youko Minamoto;E. Yokota;M. Ito;K. Dote;I. Shimizu;K. Nakanishi;S. Fujita
一位54岁女性，系统性红斑狼疮（SLE）病史21年，因皮下和牙龈出血入住松山红十字医院。根据延长的活化部分凝血活素时间（APTT）和因子VIII抑制剂，她被诊断为获得性因子VIII抑制剂。患者接受类固醇脉冲和凝血因子VIII血浆浓缩治疗，不久后因胆囊血肿转至爱媛大学医院。虽然患者的APTT和因子VIII活性在人因子VIII治疗后有所改善，但患者死于多器官衰竭。尸检显示是胆囊破裂。
A 54-year-old woman with a 21-year history of systemic lupus erythematosus (SLE) was admitted to the Matsuyama Red Cross Hospital due to subcutaneous and gingival hemorrhaging. She was diagnosed with acquired factor VIII inhibitors based on a prolonged activated partial-thromboplastin time (APTT) and factor VIII inhibitors. Steroid pulse and factor VIII plasma concentrate were administered to her, not long after which she was transferred to Ehime University Hospital due to gallbladder hematoma. Although her APTT and factor VIII activity were improved after treatment with human factor VIII, she died of multiple organ failure. The autopsy demonstrated a ruptured gallbladder.