Lifetime cocaine use and cardiovascular characteristics among young adults: The CARDIA study
Lifetime cocaine use and cardiovascular characteristics among young adults: The CARDIA study
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DOI：
10.2105/ajph.87.4.629
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发表时间：
1997-04-01
影响因子：
12.7
通讯作者：
Sidney, S
中科院分区：
文献类型：
--
作者：
Braun, BL;Murray, DM;Sidney, S
目标.可卡因是一种中枢神经系统兴奋剂，与心血管疾病风险因素、发病率和死亡率相关。尽管有这些已证实的关系，但很难评估可卡因使用的长期心血管后果。年轻人冠状动脉风险发展研究提供了一个机会，以评估终身可卡因使用与心血管疾病危险因素之间的关系，该研究随机抽样了1987年20至32岁不同社会经济地位的男性和女性的双种族队列。更广泛的可卡因使用经验与白色，年龄较大，受教育程度较低有关，无论性别如何。那些报告更广泛可卡因经验的人报告了更高水平的合法和非法物质使用行为;然而，大多数心血管疾病风险因素，如收缩压和舒张压，心率，高血压，体力活动和人体测量与终身可卡因经验无关。在这个年龄组中，可卡因对心血管的有害影响可能仅限于急性影响。需要进一步的研究来确定持续暴露是否与以后生活中的心血管疾病风险因素有关。
Objectives. Cocaine is a central nervous system stimulant associated with cardiovascular disease risk factors, morbidity, and mortality. Despite these demonstrated relationships, it has been difficult to assess the long-term cardiovascular consequences of cocaine use.Methods. The Coronary Artery Risk Development in Young Adults study provides an opportunity to evaluate the association of lifetime cocaine use with cardiovascular disease risk factors in a randomly sampled biethnic cohort of men and women of varied socioeconomic status, aged 20 to 32 in 1987.Results. More extensive cocaine use experience was associated with being White, older, and less educated, regardless of sex. Higher levels of licit and illicit substance use behavior were reported by those reporting more extensive cocaine experience; however, most cardiovascular disease risk factors such as systolic and diastolic blood pressure, heart rate, hypertension, physical activity, and anthropometric measurements were not related to lifetime cocaine experience.Conclusions. In this age group, the detrimental cardiovascular effects of cocaine may be limited to acute effects. Further studies are needed to determine whether continued exposure is related to cardiovascular disease risk factors later in life.