Solvation dynamics in dimyristoyl-phosphatidylcholine entrapped inside a sol-gel matrix
Solvation dynamics in dimyristoyl-phosphatidylcholine entrapped inside a sol-gel matrix
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DOI：
10.1021/jp035685e
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发表时间：
2004-02-19
影响因子：
3.3
通讯作者：
Bhattacharyya, K
中科院分区：
文献类型：
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作者：
Halder, A;Sen, S;Bhattacharyya, K
研究了香豆素480（C480）在含二肉豆蔻酰磷脂酰胆碱（DMPC）的溶胶-凝胶基质中的溶剂化动力学。在DMPC存在下，发现溶胶-凝胶玻璃中的平均溶剂化时间（）为500 ps。这表明，在溶胶-凝胶基质溶剂化动力学在DMPC的存在下比在其不存在的慢。C480在DMPC包埋的TEOS溶胶-凝胶基质中的溶剂化动力学比在本体水中的DMPC脂质体中的溶剂化动力学快得多。这表明DMPC包埋的TEOS溶胶-凝胶基质与本体水中的DMPC脂质体非常不同。发现C480的转动弛豫非常快，产生非常小的初始各向异性值（r（0）= 0.08）。这表明，即使在TEOS溶胶-凝胶基质内掺入脂质后，探针C480仍保持高度移动的。
Solvation dynamics of coumarin 480 (C480) is studied in a sol-gel matrix containing dimyristoyl-phosphatidylcholine (DMPC). In the presence of DMPC, the average solvation time () in the sol-gel glass is found to be 500 ps. This indicates that in the sol-gel matrix solvation dynamics in the presence of DMPC is slower than that in its absence. The solvation dynamics of C480 in the DMPC entrapped TEOS sol-gel matrix is much faster than that in DMPC liposomes in bulk water. This suggests that the DMPC entrapped TEOS sol-gel matrix is very different from DMPC liposomes in bulk water. The rotational relaxation of C480 is found to be very fast giving rise to a very small initial anisotropy value (r(0) = 0.08). This shows that even after incorporation of lipids inside the TEOS sol-gel matrix, the probe C480 remains highly mobile.