Distribution of blood group antigens A, B, H, and I(Ma) in mucus-producing adenocarcinoma of human lung.
Distribution of blood group antigens A, B, H, and I(Ma) in mucus-producing adenocarcinoma of human lung.
复制标题
人肺产生粘液的腺癌中血型抗原 A、B、H 和 I(Ma) 的分布。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
Y. Shimosato
中科院分区：
文献类型：
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作者：
S. Hirohashi;Y. Ino;T. Kodama;Y. Shimosato
用组织化学方法研究了肺癌患者黏液中血型抗原A、B、H及其前体抗原I（Ma）的分布。除少数推定为非分泌型的患者外，支气管腺黏液细胞和支气管杯状细胞的黏液中均表达符合患者ABO状态的抗原A、B、H，而抗原I（Ma）在这些细胞中完全不表达。相比之下，相容抗原A、B和H在癌细胞中减少或不存在，但抗原I（Ma）积累。抗原I（Ma）的积累是由抗原A、B和H的不完全合成引起的，是肺部黏液中与肿瘤相关的现象，在所有检查的患者中都发现了这种现象。然而，这种积累的程度因患者而异，即使在个别病例中，肿瘤细胞也表现出明显的异质性。此外，在非o血型患者的癌细胞黏液中发现了与抗原A和抗原B缺失相关的抗原积累。在B血型患者的癌细胞黏液中也发现了与抗A血清反应的不相容血型抗原（A样抗原）的表达。
The distribution of blood group antigens A, B, and H and their precursor antigen I(Ma) in the mucus of lung cancer patients was studied histochemically. Antigens A, B, and H compatible with the ABO status of the patients were expressed in the mucus of bronchial gland mucous cells and bronchial goblet cells except in a few patients presumed to be nonsecretors , while antigen I(Ma) was not expressed at all in these cells. In contrast, compatible antigens A, B, and H were decreased or not present in cancer cells but antigen I(Ma) accumulated. Accumulation of antigen I(Ma), which resulted from incomplete synthesis of antigens A, B, and H, was a tumor-associated phenomenon in the mucus of the lung and was found in all patients examined. However, the degree of this accumulation varied from patient to patient, and tumor cells showed marked heterogeneity even in an individual case. In addition, accumulation of antigen associated with loss of antigens A and B was demonstrated in cancer cell mucus of patients with a blood group status other than O. Expression of incompatible blood group antigen reactive with anti-A serum (A-like antigen) also was detected in cancer cell mucus of blood group B patients.