Advances in chiral nanozymes: a review
Advances in chiral nanozymes: a review
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手性纳米酶的进展：综述
DOI：
10.1007/s00604-019-3922-7
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发表时间：
2019
影响因子：
5.7
通讯作者：
Fan Kelong
中科院分区：
文献类型：
--
作者：
Zhang Ruofei;Zhou Yunlong;Yan Xiyun;Fan Kelong
具有内在酶活性的纳米材料通常被称为纳米酶。与天然酶相比，它们表现出许多优点，如时间和热稳定性，可回收性，可控活性和易于大规模制备。在过去的5年中，人们做了许多努力，以提高其对手性底物的特异性。本文综述（参74篇）总结了具有手性选择性的纳米酶设计的最新进展。在介绍了纳米酶和手性选择性之后，第一大部分涵盖了基于手性化学品使用的纳米酶。接下来的两节描述了使用氨基酸和DNA作为手性配体的纳米酶。表格总结了目前已知的手性酶模拟物的动力学和选择性参数。最后一节讨论了当前的挑战，并给出了前景和展望的trends.Graphical abstraction手性纳米酶表现出的不对称催化和对映体选择性歧视的能力，通过与手性配体修饰。
Nanomaterials with intrinsic enzymatic activity are often referred to as nanozymes. They exhibit many advantages over natural enzymes such as temporal and thermal stability, recyclability, controllable activity, and ease of large-scale preparation. Many efforts have been made in the past 5 years in order to improve their specificity for chiral substrates. This review (with 74 refs.) summarizes the state of the art in the design of nanozymes with chiral selectivity. Following an introduction into nanozymes and chiral selectivity in general, a first large section covers nanozymes based on the use of chiral chemicals. The next two sections describe nanozymes using amino acids and DNA as chiral ligands. A table summarizes the kinetic and selectivity parameters of the currently known chiral enzyme mimics. A concluding section addresses current challenges, and gives perspectives and an outlook on trends.Graphical abstractChiral nanozymes exhibit the ability of asymmetric catalysis and enantioselective discrimination by modifying with chiral ligands.