Secretory defenses against Giardia lamblia.
Secretory defenses against Giardia lamblia.
复制标题
针对蓝氏贾第鞭毛虫的分泌防御。
DOI：
10.1007/978-1-4615-3838-7_30
复制
发表时间：
1991
影响因子：
--
通讯作者：
Das,S
中科院分区：
文献类型：
--
作者：
Gillin,FD;Cooper,RW;Reiner,DS;Das,S
在美国，蓝氏贾第鞭毛虫是水媒肠道疾病的主要已确认原因。然而，对革兰氏杆菌和革兰氏杆菌之间生物相互作用的了解。兰氏杆菌和宿主肠道环境有限。我们提出，贾第鞭毛虫病临床表现和持续时间的巨大差异是由于寄生虫与这种环境中的免疫和非免疫成分相互作用所致。在体外对这些相互作用的研究已经开始产生关于寄生虫生物学方面的有价值的信息，这些方面可能决定滋养体在人类小肠中的定植和存留。如下所述，我们展示了正常母乳(NHM)2和十二指肠液3强大的非免疫性杀贾第鞭毛虫活性，并表明贾第鞭毛虫利用其他宿主肠道分泌物生存、附着、繁殖和分化4-7。
Giardia lambliais the major identified cause of waterborne enteric disease in the U.S. Nonetheless, knowledge of the biological interactions betweenG. lambliaand the host intestinal milieu is limited. We have proposed that the great variations in the clinical manifestations and duration of giardiasis are due to parasite interactions with both immune and non-immune components of this environments. Investigation of these interactionsin vitrohas begun to yield valuable information on aspects of parasite biology that may determine colonization and persistence of trophozoites in the human small intestine. As summarized below, we have demonstrated powerful non-immune giardiacidal activities of normal human milk (NHM)2and duodenal fluid3and have shown thatGiardiacan utilize certain other host intestinal secretions to survive, attach, multiply, and differentiate4–7.