Systemic lupus erythematosus and Sjogren's syndrome induced in a case by interferon-α used for the treatment of hepatitis C
Systemic lupus erythematosus and Sjogren's syndrome induced in a case by interferon-α used for the treatment of hepatitis C
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DOI：
10.1177/0961203309353172
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发表时间：
2010-05-01
期刊：
影响因子：
2.6
通讯作者：
Minota, S.
中科院分区：
文献类型：
--
作者：
Onishi, S.;Nagashima, T.;Minota, S.
一名57岁的日本女性在接受聚乙二醇干扰素-α和利巴韦林治疗慢性丙型肝炎7个月后出现皮疹、胸膜炎、全血细胞减少、腮腺肿胀和肾小球肾炎。抗SSA、抗SSB、抗Sm、抗dsDNA抗体阳性。诊断为系统性红斑狼疮和干燥综合征，开始糖皮质激素脉冲治疗，随后口服糖皮质激素。本例很可能是干扰素-a引起的系统性红斑狼疮和干燥综合征。干扰素-α在这些疾病中可能是重要的致病因素。Lupus（2010）19，753-755.
A 57-year-old Japanese woman developed skin eruption, pleuritis, pancytopenia, parotid gland swelling and glomerulonephritis after 7-month treatment with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Disease-specific autoantibodies such as anti-SSA, anti-SSB, anti-Sm and anti-dsDNA antibodies became positive. The diagnosis of systemic lupus erythematosus and Sjogren's syndrome was made and treatment with glucocorticoid pulse followed by oral glucocorticoid was started. It is highly probable that interferon-a-induced systemic lupus erythematosus and Sjogren's syndrome in this case. Interferon-alpha might be important pathogenically in these diseases. Lupus (2010) 19, 753-755.