WHY DO TUMOR-CELLS HAVE A HIGH AEROBIC GLYCOLYSIS
WHY DO TUMOR-CELLS HAVE A HIGH AEROBIC GLYCOLYSIS
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DOI：
10.1002/jcp.1040890429
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发表时间：
1976-01-01
影响因子：
5.6
通讯作者：
RACKER, E
中科院分区：
文献类型：
--
作者：
RACKER, E
在艾氏腹水细胞和其他几种肿瘤中，高有氧糖酵解是通过质膜Na+K+ATPase产生ADP和PiP来维持的。ATPase活性高是由于泵有缺陷，运行效率低。对Na+K+ATPase和其他泵ATPase作用机制的研究提出了几种可能解释效率下降的替代机制。蛋白质脂参与的可能性正在调查中。
In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and Piby the plasma membrane Na+K+ATPase. The high ATPase activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na+K+ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.