Implications of the inhibition of animal tumors by dietary zinc deficiency.
Implications of the inhibition of animal tumors by dietary zinc deficiency.
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膳食缺锌对抑制动物肿瘤的影响。
DOI：
10.1007/978-1-4684-0796-9_17
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发表时间：
1977
影响因子：
--
通讯作者：
W. Strain
中科院分区：
文献类型：
--
作者：
W. Pories;W. Dewys;A. Flynn;E. Mansour;W. Strain
由于锌是组织生长、细胞分裂、蛋白质合成以及 DNA 和 RNA 复制的必需营养素，因此它也应该在肿瘤的生长中发挥关键作用。为了验证本论文，进行了一系列实验来测试缺锌对小鼠和大鼠体内多种实体瘤和腹水瘤致死率的影响。具体来说，测试了以下模型：Walker 256大鼠癌肉瘤、实体和腹水形式； CDF 中的三种小鼠白血病（L5178yf、L1210 和 P388），雄性小鼠；和 C57BI/6 雄性小鼠的 Lewis 肺癌。接受缺锌饮食的大鼠，无论是实体模型还是腹水模型，都显示出肿瘤生长显着减少，并且伴随着存活率的显着增加。缺锌也显着延长了患有移植性白血病的小鼠的存活时间。此外，Lewis肺癌的生长受到抑制，但存活率却增加，这可能是受到缺锌的不利影响的限制。结果表明，肿瘤抑制是缺锌的普遍效应，与细胞类型、细胞生长速率、物种或生长部位无关。锌代谢在癌症的诊断、治疗和理解方面有许多潜在的应用。
Because zinc is an essential nutrient for tissue growth, cellular division, protein synthesis, and DNA and RNA replication, it also ought to play a critical role in the growth of tumors. To test this thesis, a series of experiments were performed to test the effect of zinc deficiency on the lethality of a variety of solid and ascites tumors in mice and rats. Specifically, the following models were tested: Walker 256 carcinosarcomas, solid and ascites forms in rats; three mouse leukemias (L5178yf, L1210, and P388) in CDF, male mice; and Lewis lung carcinoma in C57BI/6 male mice. Rats receiving a zinc-deficient diet showed marked reduction of tumor growth, both of solid or ascites models, and this was accompanied by striking increase in survival. Survival of mice with transplanted leukemia was also significantly prolonged by zinc deficiency. In addition, growth of the Lewis lung carcinoma was inhibited, but the survival through increased, was probably limited by the adverse effects of zinc deficiency. The results suggest that tumor inhibition is a general effect of zinc deficiency, irrespective of cell type, cell growth rate, species, or site of growth. There are numerous potential applications of zinc metabolism to the diagnosis, therapy, and understanding of cancer.