Protecting healthcare workers during COVID-19 pandemic with nanotechnology: A protocol for a new device from Egypt
Protecting healthcare workers during COVID-19 pandemic with nanotechnology: A protocol for a new device from Egypt
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DOI：
10.1016/j.jiph.2020.07.015
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发表时间：
2020-09-01
影响因子：
6.7
通讯作者：
Uskokovic, Vuk
中科院分区：
文献类型：
--
作者：
Ahmed, Mohamed K.;Afifi, Mohamed;Uskokovic, Vuk
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）爆发被认为于2019年12月首先发生在中国武汉，然后在随后的几个月内蔓延到120多个国家。世界卫生组织于2020年1月31日宣布其为“国际关注的突发公共卫生事件”，并于2020年3月11日确认为大流行病。SARS-CoV-2在人与人之间传播的主要途径是通过吸入呼吸道飞沫。设计保护技术来阻止含有病毒颗粒的气溶胶液滴的传播是遏制正在发生的疫情的一个至关重要的要求。然而，目前使用的几代防护性呼吸器面罩因其不完美的设计而闻名，因此需要开发更先进的类似物，具有更高的阻断效率和灭活所捕获的细菌和病毒的能力。这种设计很可能会受到纳米技术的启发。在这里，我们描述了一种来自埃及的新设计，利用可重复使用，可回收，可定制，抗菌和抗病毒的呼吸器面罩，可用于大规模生产。新的设计是基于由聚乳酸和醋酸纤维素的纳米纤维基质组成的过滤系统，含有氧化铜纳米颗粒和氧化石墨烯纳米片，并使用静电纺丝技术生产。同时，由热塑性复合材料制成的平面图案用于提供与面部解剖结构的牢固配合。这种设计说明了在发展中的环境中所做的努力，为抗击可能具有全球意义的SARS-CoV-2大流行提供创新的解决方案。(C)2020由Elsevier Ltd代表沙特国王本阿卜杜勒阿齐兹健康科学大学出版。
The outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thought to have occurred first in Wuhan, China in December 2019, before spreading to over 120 countries in the months that followed. It was declared a "public health emergency of international concern" by the World Health Organization on January 31, 2020 and recognized as a pandemic on March 11, 2020. The primary route of SARS-CoV-2 transmission from human to human is through inhalation of respiratory droplets. Devising protective technologies for stopping the spread of the droplets of aerosol containing the viral particles is a vital requirement to curb the ongoing outbreak. However, the current generations of protective respirator masks in use are noted for their imperfect design and there is a need to develop their more advanced analogues, with higher blockage efficiency and the ability to deactivate the trapped bacteria and viruses. It is likely that one such design will be inspired by nanotechnologies. Here we describe a new design from Egypt, utilizing a reusable, recyclable, customizable, antimicrobial and antiviral respirator facial mask feasible for mass production. The novel design is based on the filtration system composed of a nanofibrous matrix of polylactic acid and cellulose acetate containing copper oxide nanoparticles and graphene oxide nanosheets and produced using the electrospinning technique. Simultaneously, the flat pattern fabricated from a thermoplastic composite material is used to provide a solid fit with the facial anatomy. This design illustrates an effort made in a developing setting to provide innovative solutions for combating the SARS-CoV-2 pandemic of potentially global significance. (C) 2020 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.