Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei
Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei
复制标题
假基因衍生的小干扰 RNA 调节非洲布氏锥虫的基因表达
DOI：
10.1073/pnas.1103894108
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发表时间：
2011-05-17
影响因子：
11.1
通讯作者：
Lun, Zhao-Rong
中科院分区：
文献类型：
--
作者：
Wen, Yan-Zi;Zheng, Ling-Ling;Lun, Zhao-Rong
Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.
