Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training
Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training
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DOI：
10.1016/j.neuroimage.2021.118733
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发表时间：
2021-11-26
期刊：
影响因子：
5.7
通讯作者：
Yoshimoto, Junichiro
中科院分区：
文献类型：
--
作者：
Nakano, Takashi;Takamura, Masahiro;Yoshimoto, Junichiro
神经反馈（NF）能力倾向是指个体通过NF训练改变大脑活动的能力，据报道，NF能力倾向在人与人之间存在显著差异。个体NF倾向的预测在筛选适合NF治疗的患者的临床应用中至关重要。在本研究中，我们提取了静息态功能性脑连接（FC）标记NF的能力，独立于NF靶向脑区。我们结合了fMRI-NF研究的数据，这些研究针对两个独立站点的四个不同脑区（从59名健康成年人和6名重度抑郁症患者中获得），以收集与随后的fMRI-NF训练中的能力倾向评分相关的静息态fMRI数据。然后，我们训练的多元回归模型预测个人NF能力得分从休息状态的功能磁共振成像数据使用的发现数据集从一个网站，并确定了六个休息状态FC预测NF能力。随后，预测模型的重现性进行了验证，使用独立的测试数据从另一个网站。该模型揭示了后扣带皮层是各脑区之间的功能中枢，并形成了预测性静息态功能块，提示NF能力倾向可能参与了无任务静息态脑活动中注意模式-定向调制系统的特征。
Neurofeedback (NF) aptitude, which refers to an individual's ability to change brain activity through NF train-ing, has been reported to vary significantly from person to person. The prediction of individual NF aptitudes is critical in clinical applications to screen patients suitable for NF treatment. In the present study, we extracted the resting-state functional brain connectivity (FC) markers of NF aptitude, independent of NF-targeting brain re-gions. We combined the data from fMRI-NF studies targeting four different brain regions at two independent sites (obtained from 59 healthy adults and six patients with major depressive disorder) to collect resting-state fMRI data associated with aptitude scores in subsequent fMRI-NF training. We then trained the multiple regression models to predict the individual NF aptitude scores from the resting-state fMRI data using a discovery dataset from one site and identified six resting-state FCs that predicted NF aptitude. Subsequently, the reproducibility of the prediction model was validated using independent test data from another site. The identified FC model re-vealed that the posterior cingulate cortex was the functional hub among the brain regions and formed predictive resting-state FCs, suggesting that NF aptitude may be involved in the attentional mode-orientation modulation system's characteristics in task-free resting-state brain activity.