Gold Nanoparticles Functionalized with Gadolinium Chelates as High-Relaxivity MRI Contrast Agents
Gold Nanoparticles Functionalized with Gadolinium Chelates as High-Relaxivity MRI Contrast Agents
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DOI：
10.1021/ja904094t
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发表时间：
2009-08-12
影响因子：
15
通讯作者：
Helm, Lothar
中科院分区：
文献类型：
--
作者：
Moriggi, Loick;Cannizzo, Caroline;Helm, Lothar
顺磁钆功能化的水分散金纳米颗粒已经得到了充分的表征，NMRD谱显示出高达1.5 t的极高弛豫度。利用TEM图像和动态光散射表征表明，颗粒尺寸分布在2至15 nm之间。纳米粒子的金核对整体磁矩的贡献不大。
Water-dispersible gold nanoparticles functionalized with paramagnetic gadolinium have been fully characterized, and the NMRD profiles show very high relaxivities up to 1.5 T. Characterization using TEM images and dynamic light scattering indicate a particle size distribution from 2 to 15 nm. The gold cores of the nanoparticles do not contribute significantly to the overall magnetic moment.