ATHEROSCLEROTIC DISEASE OF THE AORTIC-ARCH AND THE RISK OF ISCHEMIC STROKE
ATHEROSCLEROTIC DISEASE OF THE AORTIC-ARCH AND THE RISK OF ISCHEMIC STROKE
复制标题
DOI：
10.1056/nejm199412013312202
复制
发表时间：
1994-12-01
影响因子：
158.5
通讯作者：
BOUSSER, MG
中科院分区：
文献类型：
--
作者：
AMARENCO, P;COHEN, A;BOUSSER, MG
背景。主动脉弓的动脉粥样硬化性疾病被怀疑是脑栓塞的潜在来源。我们进行了一项量化与主动脉弓动脉粥样硬化性疾病相关的缺血性卒中风险的研究。使用经食管超声心动图，我们对250例连续入院的缺血性卒中患者和250例连续的对照组进行了一项前瞻性病例对照研究，研究了升主动脉和近弓动脉粥样硬化斑块的频率和厚度，这些患者的年龄都在60岁以上。在14.4%的患者中发现了厚度大于或等于4毫米的动脉粥样硬化斑块，而在对照组中只有2%。在校正动脉粥样硬化危险因素后，这些斑块患者发生缺血性卒中的优势比为9.1(95%可信区间，3.3 - 25.2；P
Background. Atherosclerotic disease of the aortic arch has been suspected to be a potential source of cerebral emboli. We conducted a study to quantify the risk of ischemic stroke associated with atherosclerotic disease of the aortic arch.Methods. Using transesophageal echocardiography, we performed a prospective case-control study of the frequency and thickness of atherosclerotic plaques in the ascending aorta and proximal arch in 250 consecutive patients admitted to the hospital with ischemic stroke and 250 consecutive controls, all over the age of 60 years.Results. Atherosclerotic plaques greater than or equal to 4 mm in thickness were found in 14.4 percent of the patients but in only 2 percent of the controls. After adjustment for atherosclerotic risk factors, the odds ratio for ischemic stroke among patients with such plaques was 9.1 (95 percent confidence interval, 3.3 to 25.2; P