Association between peri-conceptional bisphenol A exposure in women and men and time to pregnancy-The HOPE study.
Association between peri-conceptional bisphenol A exposure in women and men and time to pregnancy-The HOPE study.
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DOI：
10.1111/ppe.12578
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发表时间：
2019-08
影响因子：
2.8
通讯作者：
D. Yeum;Shinyoung Ju;K. Cox;Yue Zhang;J. Stanford;C. Porucznik
中科院分区：
文献类型：
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作者：
D. Yeum;Shinyoung Ju;K. Cox;Yue Zhang;J. Stanford;C. Porucznik
双酚A（BPA）是一种非持久性内分泌干扰化学品，几乎无处不在，无意识的暴露。先前的研究表明，BPA会导致动物模型中的生殖功能障碍，但关于BPA暴露对人类妊娠时间（TTP）的影响的数据有限。目的评价女性和男性围孕期BPA暴露与夫妻TTP的关系。方法：共有164对异性恋夫妇（164名女性; 163名男性），他们有BPA信息，以及从家庭观察围受孕期暴露（HOPE）研究怀孕的时间，并随访至12个月。妇女从受孕窗口开始收集第一次晨尿样本，并持续到月经开始或估计排卵日（EDO+18天）后18天。入组后的至妊娠时间（TTP）是自我报告的，并用于分析。进行离散时间考克斯比例风险模型，以在调整教育和年龄后生成BPA和TTP之间的生育率比值比（FOR），考虑正确删失和先前尝试怀孕的周期数。结果164对夫妇中，125对夫妇在研究期间怀孕。在调整教育和年龄后，男性（FOR 1.02，95% CI 0.72，1.47）和女性（FOR 1.07，95% CI 0.75，1.53）的TTP和围受孕期BPA暴露之间没有关联。结论：在这个相对年轻、健康的怀孕计划者的孕前队列中，未发现围受孕期BPA暴露与生育能力之间存在关联。
BACKGROUND Bisphenol A (BPA) is a non-persistent endocrine-disrupting chemical with nearly ubiquitous, involuntary exposure. Previous studies have shown that BPA causes reproductive dysfunction in animal models, but there are limited data regarding the effects of BPA exposure on time to pregnancy (TTP) in humans. OBJECTIVE To evaluate whether peri-conceptional BPA exposure of women and men is associated with couples' TTP. METHODS A total of 164 heterosexual couples (164 women; 163 men) who have available BPA information as well as time to pregnancy from the Home Observation of Peri-conceptional Exposures (HOPE) Study were included and were followed up to 12 months. Women collected first-morning urine samples starting at the beginning of the fertile window and continued until the onset of menses or 18 days after the estimated day of ovulation (EDO+18 days). The time to pregnancy (TTP) after the enrolment was self-reported and used for the analysis. Discrete-time Cox proportional hazards models were performed to generate fecundability odds ratio (FOR) between BPA and TTP after adjusting for education and age, accounting for right censoring and prior number of cycles trying to conceive. RESULTS Among 164 couples, 125 couples became pregnant during the study. There was no association between TTP and peri-conceptional BPA exposure for both men (FOR 1.02, 95% CI 0.72, 1.47) and women (FOR 1.07, 95% CI 0.75, 1.53) after adjusting for education and age. CONCLUSIONS No association was found between peri-conceptional BPA exposure and fecundability in this preconception cohort of relatively young, healthy pregnancy planners.