SERS-Based Diagnosis and Biodetection
SERS-Based Diagnosis and Biodetection
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DOI：
10.1002/smll.200901820
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发表时间：
2010-03-08
期刊：
影响因子：
13.3
通讯作者：
Liz-Marzan, Luis M.
中科院分区：
文献类型：
--
作者：
Alvarez-Puebla, Ramon A.;Liz-Marzan, Luis M.
表面增强拉曼散射（Sers）光谱是用于鉴定分子种类的最强大的分析技术之一，具有在环境条件下实现单分子检测的潜力。这篇概念文章简要介绍和讨论了Sers在诊断和生物检测方面的最新进展和局限性，从直接传感到编码纳米颗粒的使用，特别关注相关生物分析物的超检测，疾病的快速诊断，单个细胞内细胞器的标记，以及活动物异常组织的非侵入性标记。
Surface-enhanced Raman scattering (SERS) spectroscopy is one of the most powerful analytical techniques for identification of molecular species, with the potential to reach single-molecule detection under ambient conditions. This Concept article presents a brief introduction and discussion of both recent advances and limitations of SERS in the context of diagnosis and biodetection, ranging from direct sensing to the use of encoded nanoparticles, in particular focusing on ultradetection of relevant bioanalytes, rapid diagnosis of diseases, marking of organelles within individual cells, and non-invasive tagging of anomalous tissues in living animals.