INPUT IMPEDANCE AND PERIPHERAL INHOMOGENEITY OF DOG LUNGS
INPUT IMPEDANCE AND PERIPHERAL INHOMOGENEITY OF DOG LUNGS
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DOI：
10.1152/jappl.1992.72.1.168
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发表时间：
1992-01-01
影响因子：
3.3
通讯作者：
FREDBERG, JJ
中科院分区：
文献类型：
--
作者：
HANTOS, Z;DAROCZY, B;FREDBERG, JJ
气管压力，中央气流，和肺泡囊压力在心脏叶开胸犬在0.1至20赫兹的伪随机强迫振荡施加在气道开口。在0.1-4.15 Hz区间内，输入阻抗数据由四参数模型拟合，包括与频率无关的气道阻力和惯性以及具有显著的阻力负频率依赖性和弹性随频率轻微升高的组织部分。该模型在对照状态和组胺输注期间都得到了良好的拟合。与此同时，区域传递阻抗（肺泡压力-中心气流比）显示叶内和叶间变异程度相似，随频率增加，并在组胺输注过程中被夸大。模拟研究的结果的基础上的肺模型，包括一个中央气道和一些周边单位的气道和组织参数，被赋予独立的广泛的分布与实验结果一致，并表明，即使是一个非常不均匀的肺结构可以产生几乎均匀的机械行为的输入。
Tracheal pressure, central airflow, and alveolar capsule pressures in cardiac lobes were measured in open-chest dogs during 0.1- to 20-Hz pseudorandom forced oscillations applied at the airway opening. In the interval 0.1-4.15 Hz, the input impedance data were fitted by four-parameter models including frequency-independent airway resistance and inertance and tissue parts featuring a marked negative frequency dependence of resistance and a slight elevation of elastance with frequency. The models gave good fits both in the control state and during histamine infusion. At the same time, the regional transfer impedances (alveolar pressure-to-central airflow ratios) showed intralobar and interlobar variabilities of similar degrees, which increased with frequency and were exaggerated during histamine infusion. Results of simulation studies based on a lung model consisting of a central airway and a number of peripheral units with airway and tissue parameters that were given independent wide distributions were in agreement with the experimental findings and showed that even an extremely inhomogeneous lung structure can produce virtually homogeneous mechanical behavior at the input.