MR properties of 19 F C3 F8 gas in the lungs of healthy volunteers: T 2 * and apparent diffusion coefficient at 1.5T and T 2 * at 3T.
MR properties of 19 F C3 F8 gas in the lungs of healthy volunteers: T 2 * and apparent diffusion coefficient at 1.5T and T 2 * at 3T.
复制标题
健康志愿者肺部中 19 F C3 F8 气体的 MR 特性：1.5T 时的 T 2 * 和表观扩散系数以及 3T 时的 T 2 *。
DOI：
10.1002/mrm.28511
复制
发表时间：
2021
影响因子：
3.3
通讯作者：
Maunder A
中科院分区：
文献类型：
--
作者：
Maunder A
目的测量19 F-C3 F8气体在1.5T和3 T下在体人肺内的横向弛豫时间（T_1）和表观扩散系数（ADC）。方法用19 F-C3 F8对肺功能残气量（FRC）和肺总容量（TLC）的肺充气水平下的ADC值进行绘制，在1.5T时，8名受试者的平均寿命为129 μ m，6名受试者的平均寿命为129 μ m。 在1.5T（FRC和TLC）下对8名受试者和3 T（TLC）下对7名受试者进行19 F-C3 F8标测。结果在FRC和TLC下，19 F-C3 F8 ADC均小于自由扩散系数，表明气道微结构扩散受限。从FRC到TLC，19 F-C3 F8的平均ADC从1.56 mm 2/s显著增加到1.83 mm 2/s（P= .0017），129 mA从2.49 mm 2/s显著增加到3.38 mm 2/s（P= .0015）。FRC与TLC在上级半肺中的ADC的后-前梯度测量值分别为0.0308 mm 2/s/cm与0.0168 mm 2/s/cm（19 F-C3 F8）和0.0871 mm 2/s/cm与0.0326 mm 2/s/cm（129 mm）。在肺中观察到19 F-C3 F8值的一致分布，在隔膜和大肺血管附近观察到低值。1.5T时FRC和TLC的平均值分别为4.48 ms和5.33 ms，3 T时TLC的平均值为3.78 ms。结论在本可行性研究中，建立了健康志愿者C3 F8在体肺成像的MRI（和ADC）可测量的肺微结构生理相关参数值。
PurposeTo measure the transverse relaxation time () and apparent diffusion coefficient (ADC) of19F‐C3F8gas in vivo in human lungs at 1.5T and 3T, and to determine the representative distribution of values of these parameters in a cohort of healthy volunteers.MethodsMapping of ADC at lung inflation levels of functional residual capacity (FRC) and total lung capacity (TLC) was performed with inhaled19F‐C3F8(eight subjects) and129Xe (six subjects) at 1.5T. mapping with19F‐C3F8was performed at 1.5T (at FRC and TLC) for 8 subjects and at 3T (at TLC for seven subjects).ResultsAt both FRC and TLC, the19F‐C3F8ADC was smaller than the free diffusion coefficient demonstrating airway microstructural diffusion restriction. From FRC to TLC, the mean ADC significantly increased from 1.56 mm2/s to 1.83 mm2/s (P= .0017) for19F‐C3F8,and from 2.49 mm2/s to 3.38 mm2/s (P= .0015) for129Xe. The posterior‐to‐anterior gradient in ADC for FRC versus TLC in the superior half of the lungs was measured as 0.0308 mm2/s per cm versus 0.0168 mm2/s per cm for19F‐C3F8and 0.0871 mm2/s per cm versus 0.0326 mm2/s per cm for129Xe. A consistent distribution of19F‐C3F8values was observed in the lungs, with low values observed near the diaphragm and large pulmonary vessels. The mean across volunteers was 4.48 ms at FRC and 5.33 ms at TLC for 1.5T, and 3.78 ms at TLC for 3T.ConclusionIn this feasibility study, values of physiologically relevant parameters of lung microstructure measurable by MRI (, and ADC) were established for C3F8in vivo lung imaging in healthy volunteers.