Internal capsule size in good-outcome and poor-outcome schizophrenia
Internal capsule size in good-outcome and poor-outcome schizophrenia
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DOI：
10.1176/appi.neuropsych.18.3.364
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发表时间：
2006-06-01
影响因子：
2.9
通讯作者：
Shihabuddin, Lina
中科院分区：
文献类型：
--
作者：
Brickman, Adam M.;Buchsbaum, Monte S.;Shihabuddin, Lina
多项研究表明，白质异常可能是精神分裂症病理生理学的核心。本研究的目的是检测精神分裂症患者内囊前肢的局部白质。作者对106名精神分裂症患者和42名年龄和性别匹配的健康对照受试者进行了高分辨率磁共振成像。内囊前肢的面积是在五个背侧到腹侧水平按比例间隔测量的。根据对精神分裂症患者自我护理缺陷的纵向分析，将患者分为预后良好组和预后不良组。预后不良的患者的背部面积明显小于健康对照组，但预后良好的患者与健康对照组没有区别。在健康对照受试者和预后良好的患者中，尾状核、壳核和丘脑的相对体积较大往往与内囊相对较大的体积有关，这与已知的额叶-纹状体-丘脑通路一致。较大的脑室与较小的内囊有关，特别是在健康对照受试者中。这一发现表明，预后不良的精神分裂症患者的内囊纤维断裂。这些异常可能与精神分裂症的其他结构变化无关。
Converging lines of research suggest that white matter abnormalities may be central to the pathophysiology of schizophrenia. The purpose of this study was to examine regional white matter in the anterior limb of the internal capsules in patients with schizophrenia. The authors obtained high-resolution magnetic resonance imaging in 106 patients with schizophrenia and 42 age and sex-matched healthy comparison subjects. The area of the anterior limb of the internal capsule was measured at five proportionately spaced dorsal-to-ventral levels. Schizophrenia patients were divided into good-outcome and poor-outcome groups, based on longitudinal analysis of self-care deficits. Patients with poor-outcome had significantly smaller dorsal areas than healthy comparison subjects, but good-outcome patients did not differ from healthy comparison subjects. Larger relative volumes of the caudate, putamen, and thalamus tended to be associated with relatively larger volumes of the internal capsule in healthy comparison subjects and good-outcome patients, consistent with the known frontal-striatal-thalamic pathways. Larger ventricles were associated with smaller internal capsules, particularly in healthy comparison subjects. The findings suggest disruption of internal capsule fibers in poor-outcome patients with schizophrenia. These abnormalities may be independent of other structural changes in schizophrenia.