DATA-DRIVEN APPROACH TO GENERATING ACHIEVABLE DOSE-VOLUME HISTOGRAM OBJECTIVES IN INTENSITY-MODULATED RADIOTHERAPY PLANNING
DATA-DRIVEN APPROACH TO GENERATING ACHIEVABLE DOSE-VOLUME HISTOGRAM OBJECTIVES IN INTENSITY-MODULATED RADIOTHERAPY PLANNING
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DOI：
10.1016/j.ijrobp.2010.05.026
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发表时间：
2011-03-15
影响因子：
7
通讯作者：
McNutt, Todd
中科院分区：
文献类型：
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作者：
Wu, Binbin;Ricchetti, Francesco;McNutt, Todd
目的：提出一种调强放射治疗(IMRT)计划的方法，该方法利用包含既往患者几何和剂量学信息的数据库来生成可实现的剂量体积直方图(DVH)目标。方法和材料：使用重叠体积直方图(OVH)来比较数据库中新患者的危险器官和靶区之间的空间关系。根据OVH分析，从数据库中生成新患者的DVH目标，并将其用作初始计划目标。在一项回顾的OVH辅助计划演示中，从包含91名头颈部患者的临床计划(CP)的数据库中随机选择了15名患者，这些患者接受了三级调强放疗-同步集成Boost技术的治疗。OVH辅助计划(OP)是由对CPS一无所知的计划者以一刀切的方式计划的。因此，OP的DVH目标是从子数据库中生成的，该子数据库包含其他90名患者的信息。这些DVH目标随后被用作IMRT优化的初始计划目标。通过规划过程中“开始优化”按钮的点击次数来评价规划效率。虽然顶峰(3)治疗计划系统允许计划人员在优化过程中交互调整DVH参数，但我们机构的计划人员从未在计划中使用过这一功能。结果：完成CP和OP所需的平均点击次数分别为27.6和1.9(p
Purpose: To propose a method of intensity-modulated radiotherapy (IMRT) planning that generates achievable dose volume histogram (DVH) objectives using a database containing geometric and dosimetric information of previous patients.Methods and Materials: The overlap volume histogram (OVH) is used to compare the spatial relationships between the organs at risk and targets of a new patient with those of previous patients in a database. From the OVH analysis, the DVH objectives of the new patient were generated from the database and used as the initial planning goals. In a retrospective OVH-assisted planning demonstration, 15 patients were randomly selected from a database containing clinical plans (CPs) of 91 previous head-and-neck patients treated by a three-level IMRT-simultaneous integrated boost technique. OVH-assisted plans (OPs) were planned in a leave-one-out manner by a planner who had no knowledge of CPs. Thus, DVH objectives of an OP were generated from a subdatabase containing the information of the other 90 patients. Those DVH objectives were then used as the initial planning goals in IMRT optimization. Planning efficiency was evaluated by the number of clicks of the "Start Optimization" button in the course of planning. Although the Pinnacle(3) treatment planning system allows planners to interactively adjust the DVH parameters during optimization, planners in our institution have never used this function in planning.Results: The average clicks required for completing the CP and OP was 27.6 and 1.9, respectively (p