Prevalence and clinical aspects of Behcet's disease in the north of Israel
Prevalence and clinical aspects of Behcet's disease in the north of Israel
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DOI：
10.1007/s10067-006-0349-4
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发表时间：
2007-04-01
影响因子：
3.4
通讯作者：
Weinberger, Abraham
中科院分区：
文献类型：
--
作者：
Krause, Ilan;Yankevich, Anna;Weinberger, Abraham
白塞氏病（BD）在古丝绸之路沿着国家的患病率较高，但在以色列的实际患病率尚不清楚。我们评估了以色列北方地区BD的发生率和临床表现：在整个人群和种族群体中。样本包括在以色列北方三个医疗中心接受治疗的所有BD（国际研究组标准）成人患者。通过文件审查和医生调查收集患者数据。医疗中心服务人口的相关人口统计数据来自以色列官方当局。共确定了112名患者。BD的总体患病率为15.2/100，000，男性和女性相似。犹太人、阿拉伯人和德鲁兹人的患病率分别为每10万人8.6、26.2和146.4。所有种族组的发病年龄相似，男性发病年龄显著较低（28.6 +/- 9.7 vs 32.9 +/- 11.3，p=0.03）。不同性别或种族的疾病表现没有差异。所有德鲁兹患者HLA-B5阳性，而阿拉伯患者为80.8%，犹太患者为72.0%。家庭成员复发性口腔溃疡在阿拉伯患者中更常见（p=0.004）。德鲁兹患者的BD严重程度指数显著较低（p=0.05），主要是男性（p=0.03）。这项研究证实了BD在以色列的高患病率以及疾病率和种族表达的变异性。我们的调查结果，特别是关于德鲁兹人的调查结果，要求进一步进行实地调查和遗传研究。
Behcet's disease (BD) has a higher prevalence in countries along the ancient silk route, but the actual prevalence in Israel is unknown. We evaluated the occurrence and clinical expression of BD in the northern region of Israel: in the whole population and by ethnic groups. The sample included all adult patients with BD (International Study Group criteria) treated at three medical centers in northern Israel. Patient data were collected by file review and physician survey. Relevant demographic data for the population served by the medical centers were obtained from the official Israeli authorities. A total of 112 patients were identified. The overall prevalence of BD was 15.2/100,000 and was similar in men and women. The prevalence rates among the Jewish, Arab, and Druze populations were 8.6, 26.2, and 146.4 per 100,000, respectively. Age at disease onset was similar in all ethnic groups and significantly lower in males (28.6 +/- 9.7 vs 32.9 +/- 11.3, p=0.03). There were no differences in disease manifestations by sex or ethnicity. All Druze patients were HLA-B5 positive, compared to 80.8% of the Arab patients and 72.0% of the Jewish patients. Recurrent oral ulcers in family members were more common in Arab patients (p=0.004). The BD severity index was significantly lower in Druze patients (p=0.05), mainly in males (p=0.03). This study confirms the high prevalence of BD in Israel and the variability in disease rates and expression by ethnic origin. Our findings, particularly regarding the Druze population, call for further field surveys and genetic studies.