Invasive growth: from development to metastasis
Invasive growth: from development to metastasis
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DOI：
10.1172/jci200215392
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发表时间：
2002-04-01
影响因子：
15.9
通讯作者：
Trusolino, L
中科院分区：
文献类型：
--
作者：
Comoglio, PM;Trusolino, L
生理和病理条件下的侵入性生长程序。在这两种情况下，侵入性生长都是由类似的生物过程细胞-细胞分离和迁移，细胞增殖和存活引起的，但终点不同。正常细胞利用侵入性生长来定殖新的领域并建立极化的三维结构，从而形成几个器官的实质结构。癌细胞异常地执行这一程序以渗透邻近环境并形成转移。
The invasive growth program under physiological and pathological conditions. In both settings, invasive growth results from analogous biological processes–cell-cell dissociation and migration, cell multiplication, and survival–but the endpoints are different. Normal cells exploit invasive growth to colonize new territories and build polarized three-dimensional structures, thus forming the parenchymal architecture of several organs. Cancer cells implement this program aberrantly to infiltrate the adjacent surroundings and form metastases.