Drimane Sesquiterpenoids from the Fungus Aspergillus ustus Isolated from the Marine Sponge Suberites domuncula
Drimane Sesquiterpenoids from the Fungus Aspergillus ustus Isolated from the Marine Sponge Suberites domuncula
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DOI：
10.1021/np900220r
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发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Proksch, Peter
中科院分区：
文献类型：
--
作者：
Liu, Hongbing;Edrada-Ebel, RuAngelie;Proksch, Peter
从海绵海绵中分离得到7个新的倍半萜类化合物（1- 3,6 -9），以及已知化合物脱氧维苷B(4)、双内酯B(5)和RES-1149-2（10）。化合物6、7和10对肿瘤细胞系L5178Y、HeLa和PC12细胞具有细胞毒活性，其中化合物7对L5178Y细胞系EC50为0.6 μ g/mL，活性最强。
Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 mu g/mL).