Assessment of the Ability of a Fourth-Generation Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and p24 Antigen To Detect both Acute and Recent HIV Infections in a High-Risk Setting
Assessment of the Ability of a Fourth-Generation Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and p24 Antigen To Detect both Acute and Recent HIV Infections in a High-Risk Setting
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DOI：
10.1128/jcm.00119-09
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发表时间：
2009-08-01
影响因子：
9.4
通讯作者：
Klausner, Jeffrey D.
中科院分区：
文献类型：
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作者：
Pandori, Mark W.;Hackett, John, Jr.;Klausner, Jeffrey D.
通过使用从近期感染HIV 1型（HIV-1）的个体中采集的一组标本，评价了同时检测人类免疫缺陷病毒（HIV）抗体和HIV p24抗原（Architect HIV Ag/Ab Combo）的免疫测定（IA）检测HIV感染的能力。发现该IA能够检测大多数（89%）感染，包括80%基于HIV RNA的存在和缺乏可检测的HIV抗体而被认为是急性感染的感染。与前几代IA相比，Architect HIV Ag/Ab Combo在检测近期感染方面的显著改进以及检测急性感染的能力对HIV预防策略具有重要意义。
An immunoassay (IA) that simultaneously detects both antibody to human immunodeficiency virus (HIV) and HIV p24 antigen (Architect HIV Ag/Ab Combo) was evaluated for its ability to detect HIV infection by using a panel of specimens collected from individuals recently infected with HIV type 1 (HIV-1). This IA was found to be capable of detecting the majority (89%) of infections, including 80% of those considered acute infections based on the presence of HIV RNA and the lack of detectable antibody to HIV. Substantial improvements in detection of recent infections by the Architect HIV Ag/Ab Combo relative to previous generations of IAs as well as the capacity to detect acute infections have important implications for HIV prevention strategies.