The No-Touch Isolation Technique of Resection
The No-Touch Isolation Technique of Resection
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非接触式隔离切除技术
DOI：
10.1001/jama.1975.03240230053026
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
R. Turnbull
中科院分区：
文献类型：
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作者：
R. Turnbull
Fisher和我，1在1955年，报告发现在肠系膜静脉血液中发现癌细胞，在25名接受切除的患者中有8名正在引流结肠肿瘤。随后，我们研究了67例结直肠癌切除患者的门静脉血，我们发现那些在切除过程中肿瘤被操纵的人的血液中发现更多的恶性细胞。我们认识到胃肠道癌侵袭门静脉根部并脱落细胞，这些细胞栓塞到肝脏，在那里它们生长为致命的转移瘤。Fisher和Fisher 2不仅证明了这些细胞，而且实验表明，当超过一定剂量的肿瘤细胞时，更有可能发生肝转移。由于我们的发现，在1953年，Fisher和Fisher，2和Cole等人，3，我们利用了
FISHER and I, 1 in 1955, reported finding cancer cells in the blood of the mesenteric veins that were draining tumors of the colon in eight of 25 patients who were undergoing resection. Subsequently, we studied the portal venous blood of 67 patients undergoing resection for colorectal cancer; we found that malignant cells were found more frequently in the blood of those whose cancer had been manipulated during resection. We recognized that carcinomas of the gastrointestinal tract invade the portal venous radicals and shed cells and that these cells embolize to the liver, where they grow as fatal metastases. Fisher and Fisher 2 not only demonstrated these cells, but also showed experimentally that the liver metastases were more likely to occur when a certain dose of tumor cells was exceeded. Because of our findings, those of Fisher and Fisher, 2 and Cole et al, 3 in 1953, we utilized a