Signaling by the phosphoinositide 3-kinase family in immune cells.
Signaling by the phosphoinositide 3-kinase family in immune cells.
复制标题
DOI：
10.1146/annurev-immunol-032712-095946
复制
发表时间：
2013
影响因子：
29.7
通讯作者：
Okkenhaug K
中科院分区：
文献类型：
--
作者：
Okkenhaug K
磷酸肌醇3-激酶控制免疫细胞发育、分化和功能的许多重要方面。哺乳动物有8个PI 3 K催化亚基，根据结构和功能的相似性分为3类。I类PI 3 K的特定作用已被广泛研究，并且相对较好地理解其相应磷酸酶的功能。最近，II类和III类PI 3 K的特定作用已经出现。通过脊椎动物的进化，并与适应性免疫的进化平行，不仅PI 3 K亚基的基因，而且作用于3-磷酸肌醇和3-磷酸肌醇结合蛋白的磷酸酶的基因都有显著增加。我们对免疫中PI 3 Ks的理解是由在更简单的模式生物中所做的基本发现以及通过欣赏这种信号模块在一般哺乳动物和特别是免疫细胞中的新适应来指导的。
Phosphoinositide 3-kinases control many important aspects of immune cell development, differentiation and function. Mammals have eight PI3K catalytic subunits which are divided into 3 classes based on similarities in structure and function. Specific roles for the class I PI3Ks have been broadly investigated and are relatively well understood as is the function of their corresponding phosphatases. More recently, specific roles for the class II and class III PI3Ks have emerged. Through vertebrate evolution and in parallel with the evolution of adaptive immunity, there has been a dramatic increase not only in the genes for PI3K subunits but also in genes for phosphatases that act on 3-phopshoinositides and on 3-phosphoinositide binding proteins. Our understanding of the PI3Ks in immunity is guided by fundamental discoveries made in simpler model organisms as well as by appreciating new adaptions of this signalling module in mammals in general and immune cells in particular.