Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity.
Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity.
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DOI：
10.3389/fphys.2020.573372
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发表时间：
2020
影响因子：
4
通讯作者：
Kornbluth J
中科院分区：
文献类型：
--
作者：
Lawrence DW;Willard PA;Cochran AM;Matchett EC;Kornbluth J
NKLAM，又名RNF19B，是E3泛素连接酶小家族中的一个独特成员。这组14个成员的连接酶具有一个特有的富含半胱氨酸的环-IBR-环(RBR)结构域，它介导多种底物的泛素化。底物泛素化的结果不同，取决于形成的泛素连接的类型。蛋白质泛素化研究最广泛的作用是蛋白酶体介导的底物降解；然而，泛素化也可以改变蛋白质的定位和功能。自1999年发现NKLAM以来，关于NKLAM在先天性免疫反应中的作用，人们已经破译了很多东西。我们已经发现NKLAM在体外和体内的自然杀伤(NK)细胞和巨噬细胞中都具有完整的功能。这些细胞类型中的每一种都需要NKLAM的表达来调节最大的杀伤活性和细胞因子的产生。然而，仍有许多事情有待确定。本文就NKLAM的表达、结构和功能等方面的研究进展作一综述，并讨论新的研究方向。我们希望这将激发人们对进一步探索NKLAM的兴趣。
Natural Killer Lytic-Associated Molecule (NKLAM), also designated RNF19B, is a unique member of a small family of E3 ubiquitin ligases. This 14-member group of ligases has a characteristic cysteine-rich RING-IBR-RING (RBR) domain that mediates the ubiquitination of multiple substrates. The consequence of substrate ubiquitination varies, depending on the type of ubiquitin linkages formed. The most widely studied effect of ubiquitination of proteins is proteasome-mediated substrate degradation; however, ubiquitination can also alter protein localization and function. Since its discovery in 1999, much has been deciphered about the role of NKLAM in innate immune responses. We have discerned that NKLAM has an integral function in both natural killer (NK) cells and macrophages in vitro and in vivo. NKLAM expression is required for each of these cell types to mediate maximal killing activity and cytokine production. However, much remains to be determined. In this review, we summarize what has been learned about NKLAM expression, structure and function, and discuss new directions for investigation. We hope that this will stimulate interest in further exploration of NKLAM.
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影响因子：
3.4
作者：
Guo M;Härtlova A;Dill BD;Prescott AR;Gierliński M;Trost M
通讯作者：
Trost M
DOI：
10.23937/2378-3672/1410018
发表时间：
2016-01-01
期刊：
International journal of immunology and immunotherapy
影响因子：
--
作者：
Gullickson, Gail;Ambrose, Elise C;Kornbluth, Jacki
通讯作者：
Kornbluth, Jacki
DOI：
10.1073/pnas.201238598
发表时间：
2001-09-25
影响因子：
11.1
作者：
Cerwenka, A;Baron, JL;Lanier, LL
通讯作者：
Lanier, LL
影响因子：
4.6
作者：
Ali, S.;Vollaard, A. M.;van Dissel, J. T.
通讯作者：
van Dissel, J. T.
影响因子：
7.2
作者：
Ambrose, Elise C.;Kornbluth, Jacki
通讯作者：
Kornbluth, Jacki