Studies of regional coronary flow using radioactive microspheres.
Studies of regional coronary flow using radioactive microspheres.
复制标题
使用放射性微球进行局部冠状动脉血流研究。
DOI：
10.1016/s0003-4975(10)63850-7
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
G. Buckberg
中科院分区：
文献类型：
--
作者：
G. Buckberg
如果心脏包含至少 400 个球体，放射性微球体可准确测量冠状动脉总血流量 (±10%)。微球方法的精度取决于感兴趣区域和参考样品中的球体数量，而不取决于放射性。如果样品至少包含 400 个球体，则可以根据从跳动、工作的心脏和体外循环期间的任何血管（颈动脉或股动脉或主动脉）收集的参考样品来计算可靠的流量。 9μ的球体像扩散指示器一样分布在心脏中，而大于9μ的球体优先流向心内膜，导致心内膜下流量被高估。使用 15 μ 球体可以减少这种高估，并且可以很容易地考虑在内。微球体方法提供有关流量（ml/100 gm 组织/分钟）的信息，并允许与其他区域（心内膜/心外膜流量比率）进行比较，但不提供有关区域流量或其分布是否充分的信息；这必须通过生化、组织化学和功能分析来评估。
Radioactive microspheres accurately measure total coronary blood flow (±10%) if the heart contains at least 400 spheres. Precision of the microsphere method depends upon the number of spheres in the region of interest and the reference sample, not on the radioactivity. Reliable flow can be calculated from reference samples collected from any vessel (carotid or femoral artery or aorta) in the beating, working heart and during cardiopulmonary bypass if the sample contains a minimum of 400 spheres. Spheres of 9 μ are distributed in the heart like diffusible indicators, while spheres greater than 9 μ preferentially stream to the endocardium, causing subendocardial flow to be overestimated. This overestimate is lessened with 15 μ spheres and can be readily taken into account.The microsphere method provides information about flow (ml/100 gm tissue/min) and allows comparisons with other regions (endocardial/epicardial flow ratios) butdoes notprovide information about the adequacy of regional flow or its distribution; this must be assessed by biochemical, histochemical, and functional analysis.