Identifying meaningful intra-individual change standards for health-related quality of life measures
Identifying meaningful intra-individual change standards for health-related quality of life measures
复制标题
DOI：
10.1046/j.1365-2753.2000.00238.x
复制
发表时间：
2000-02-01
影响因子：
2.4
通讯作者：
Wolinsky, FD
中科院分区：
文献类型：
--
作者：
Wyrwich, KW;Wolinsky, FD
虽然已经开发了许多措施，用于评估健康相关的生活质量（HRQoL），战略，以确定有意义的个体内变化，这些措施没有跟上工具的发展。因此，临床试验研究人员，质量保证评估小组和执业临床医生没有既定的标准来评估个体患者的HRQoL指标的变化，改善，稳定或下降，本文回顾和批评的方法，已被应用于建立个人内HRQoL变化标准。这些方法包括基于人内和人间锚点的研究，以及基于分布的技术，使用效应量、测量标准误差、均方误差或从分层线性模型中得出的个体斜率系数。实用的方法来改善和推进HRQoL变化的评价，提高解释内的个人变化。在这一领域的HRQoL研究的两个未来的方法学挑战进行检查：（1）通用HRQoL措施的个人变化标准的发展;（2）将个人临床评估的过程中建立显着的个人内的变化标准。
Although numerous measures have been developed for the evaluation of health-related quality of life (HRQoL), strategies for identifying meaningful intra-individual change in these measures have not kept pace with instrument development. As a result, clinical trial researchers, quality assurance assessment teams and practising clinicians are without established standards to evaluate individual patient change in HRQoL measures as improved, stable or declined, This article reviews and critiques the methods that have been applied to establish intra-individual HRQoL change standards. These methods include within-person and between-persons anchor-based studies, as well as distribution-based techniques using the effect size, the standard error of measurement, the mean squared error or individual slope coefficients derived from hierarchical linear modelling. Practical approaches to improving and advancing HRQoL change evaluations that enhance the interpretation of intra-individual change are provided. Two future methodological challenges in this area of HRQoL research are examined: (1) the development of individual change standards for generic HRQoL measures; and (2) the incorporation of individual clinical assessments into the process for establishing significant intra-individual change standards.