Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice
Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice
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DOI：
10.1016/j.drugalcdep.2017.10.034
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发表时间：
2018-02-01
影响因子：
4.2
通讯作者：
Szumlinski, Karen K.
中科院分区：
文献类型：
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作者：
Fultz, Elissa K.;Szumlinski, Karen K.
酒精使用障碍是甲基苯丙胺（MA）滥用的主要诱发因素。此外，MA-酒精共滥用是MA依赖个体治疗中止和不依从的风险因素。对于MA成瘾没有有效的治疗方法，更不用说针对患有MA-酒精成瘾共病的人的治疗了。因此，我们必须开发高通量的动物模型来研究MA和酒精之间的生物行为相互作用的病因学和治疗的共同滥用。为此，我们报道了酗酒史[5、10、20和40%（v/v）; 2小时/天，持续10-14天]减少了MA强化和摄入，但当药物可用性在行为上是非偶然的时，它增加了MA偏好和摄入。为了调和发现中的这种明显差异，我们采用了与我们先前研究中采用的类似的2周狂饮模式，随后进行了位置调节程序（0.25、0.5、1、2或4 mg/kg MA的4对，i. p.）。这是为了确定先前的酗酒史如何影响MA的情感效价和对MA诱导的精神运动激活/致敏的敏感性。先前的酗酒史钝化自发运动活动和移动的MA剂量位置偏好功能向上饮水控制。增强的MA条件奖励先前酗酒的历史是独立的任何酒精的影响后，运动激活或致敏作用的MA。基于这些结果，我们提出，我们的小组以前报告的减少MA强化可能反映了对MA的积极主观效应的敏感性增加的补偿反应，而不是对药物的精神运动激活效应的敏感性增加。
An alcohol use disorder is a major predisposing factor for methamphetamine (MA) abuse. Further, MA-alcohol co-abuse is a risk factor for treatment discontinuation and non-compliance in MA-dependent individuals. No effective treatment exists for MA addiction, let alone treatments directed at those suffering from MA-alcohol addiction co-morbidity. Thus, it is imperative that we develop high-throughput animal models to study the biobehavioral interactions between MA and alcohol of relevance to the etiology and treatment of co-abuse. To this end, we reported that a history of binge alcohol-drinking [5,10, 20 and 40% (v/v); 2 h/day for 10-14 days] reduces MA reinforcement and intake, but it augments MA-preference and intake when drug availability is behaviorally non-contingent. To reconcile this apparent discrepancy in findings, we employed a comparable 2 week binge-drinking paradigm as that employed in our previous studies followed by place-conditioning procedures (4 pairings of 0.25, 0.5, 1, 2 or 4 mg/kg MA, i.p.). This was meant to determine how a prior binge drinking history impacts the affective valence of MA and sensitivity to MA-induced psychomotor-activation/sensitization. Prior binge-drinking history blunted spontaneous locomotor activity and shifted the MA dose place-preference function upwards of water drinking controls. The potentiation of MA-conditioned reward by prior binge-drinking history was independent of any alcohol effects upon the locomotor-activating or sensitizing effects of MA. Based on these results we propose that the reduced MA reinforcement reported previously by our group likely reflects a compensatory response to an increased sensitivity to MA's positive subjective effects rather than increased sensitivity to the drug's psychomotor-activating effects.