CIRCADIAN-RHYTHM OF LIVER-GLYCOGEN METABOLISM IN RATS - EFFECTS OF HYPOTHALAMIC-LESIONS
CIRCADIAN-RHYTHM OF LIVER-GLYCOGEN METABOLISM IN RATS - EFFECTS OF HYPOTHALAMIC-LESIONS
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DOI：
10.1152/ajpendo.1980.238.1.e21
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
SHIMAZU, T
中科院分区：
文献类型：
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作者：
ISHIKAWA, K;SHIMAZU, T
以黑暗期（2000-0800 h）喂养的大鼠为研究对象，研究下丘脑视交叉上核（SCN）和腹内侧核（VMH）电解损伤对肝糖原代谢昼夜节律的影响。双侧 SCN 病变并未明显影响肝糖原代谢 3 个参数（即糖原含量、糖原合成酶 I 和磷酸化酶 a 活性）的昼夜节律。 VMH 的双侧损伤导致磷酸化酶 a 活性的昼夜节律性几乎完全丧失，降低了通常在深夜观察到的高活性。 VMH 损伤还降低了合成酶 I 活性和糖原含量的节律幅度，但并未消除它们的节律性。 VMH 的完整性（而不是 SCN）对于食物触发的肝磷酸化酶 a 活性的昼夜节律的调节或表达很重要。还讨论了下丘脑外侧核在调节肝脏合成酶 I 昼夜节律中的意义。
The effects of electrolytic lesions of the suprachiasmatic nucleus (SCN) and ventromedial nucleus (VMH) of the hypothalamus on the circadian rhythm of liver glycogen metabolism were studied in rats fed during the dark period (2000-0800 h). Bilateral lesions of the SCN did not appreciably affect the circadian rhythmicity in 3 parameters of liver glycogen metabolism, i.e., glycogen content and glycogen synthetase I and phosphorylase a activities. Bilateral lesions of the VMH resulted in almost complete loss of circadian rhythmicity in phosphorylase a activity by lowering the high activity normally observed in late evening. VMH lesions also reduced the amplitudes of the rhythms of synthetase I activity and glycogen content, but did not abolish their rhythmicities. The integrity of the VMH, rather than the SCN, is important for regulation or expression of the food-triggered circadian rhythm of liver phosphorylase a activity. The implication of the lateral hypothalamic nucleus in regulation of the circadian rhythm of liver synthetase I is also discussed.