Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients with colorectal cancer.
Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients with colorectal cancer.
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DOI：
10.1038/bjc.2013.350
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发表时间：
2013-07-23
影响因子：
8.8
通讯作者：
Kubota K
中科院分区：
文献类型：
--
作者：
Ishizuka M;Nagata H;Takagi K;Iwasaki Y;Kubota K
本研究探讨了一种新的基于炎症的预后系统，名为COP-NLR（血小板计数和中性粒细胞与淋巴细胞比率的组合），用于预测结直肠癌（CRC）患者的术后生存率。COP-NLR是根据入院当天获得的数据计算的：血小板计数升高（>30 × 104 mm−3）和NLR升高（>3）的患者被分配为2分，而显示一个或两个都没有的患者分别被分配为1分或0分。480例患者入组。单因素分析选择的临床特征的多因素分析显示，COP-NLR（1，2/0）（比值比，0.464; 95%可信区间，0.267-0.807; P=0.007）与肿瘤特异性生存率相关，沿着病理、淋巴结转移、血清癌胚抗原、C反应蛋白和白蛋白水平，和格拉斯哥预后评分。Kaplan-Meier分析和log-rank检验显示COP-NLR能够将此类患者分为3个独立组（P<0.001）。COP-NLR被认为是CRC患者术后生存的有用预测因子。
This study investigated the usefulness of a novel inflammation-based prognostic system, named the COP-NLR (COmbination of Platelet count and Neutrophil to Lymphocyte Ratio), for predicting the postoperative survival of patients with colorectal cancer (CRC). The COP-NLR was calculated on the basis of data obtained on the day of admission: patients with both an elevated platelet count (>30 × 104 mm−3) and an elevated NLR (>3) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. Four-hundred and eighty patients were enrolled. Multivariate analysis of clinical characteristics selected by univariate analysis showed that the COP-NLR (1, 2/0) (odds ratio, 0.464; 95% confidence interval, 0.267–0.807; P=0.007) had an association with cancer-specific survival, along with pathology, lymph node metastasis, the serum levels of carcinoembryonic antigen, C-reactive protein and albumin, and the Glasgow Prognostic Score. Kaplan–Meier analysis and log-rank test revealed that the COP-NLR was able to divide such patients into three independent groups (P<0.001). The COP-NLR is considered to be a useful predictor of postoperative survival in patients with CRC.
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DOI：
10.1073/pnas.94.2.663
发表时间：
1997-01-21
影响因子：
11.1
作者：
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DOI：
10.1111/igc.0b013e3181a47d47
发表时间：
2009-11-01
影响因子：
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作者：
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影响因子：
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