Osteoarthritis in Europe: impact on health status, work productivity and use of pharmacotherapies in five European countries
Osteoarthritis in Europe: impact on health status, work productivity and use of pharmacotherapies in five European countries
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DOI：
10.1093/rheumatology/ket463
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发表时间：
2014-05-01
期刊：
影响因子：
5.5
通讯作者：
Conaghan, Philip G.
中科院分区：
文献类型：
--
作者：
Kingsbury, Sarah R.;Gross, Hillary J.;Conaghan, Philip G.
目标.本研究的目的是检查外周关节OA在五个欧洲大国的影响，以及OA患者如何使用药物治疗。自报外周关节OA患者选自2011年5个欧洲国家（5EU）的国家健康与健康调查（NHWS），其中包括来自法国、德国、意大利、西班牙和英国的57512名受访者。记录症状、健康状况、卫生保健利用、工作效率和药物使用情况。所有的变量进行了分析，为总人口和个别国家。共有3750名受访者符合入选标准：1635名（43.6%）英国、961名（25.6%）法国、570名（15.2%）德国、316名（8.4%）西班牙和268名（7.1%）意大利。大多数年龄在55-74岁之间，大多数超重或肥胖。所有国家的健康状况[12项简表第2版（SF 12 v2）]相似，平均值（s.d.）40.53（10.99）; 21.5%的人自我报告患有抑郁症。大多数人在过去6个月内访问了医疗保健提供者（n = 3537; 94.3%）。三分之一的人有工作：7%的人缺勤，24%的人出勤。46.9%的患者报告使用处方药治疗OA，26.5%的患者报告使用非处方药（OTC），9.4%的患者报告两者均使用。药物的使用随着疼痛的严重程度而增加。NSAID是最常用的药物。类阿片使用率从意大利的1.8%到法国的54.5%不等。50%的人报告完全依从（4分Morisky药物依从性量表），但只有30%的人报告对他们的OA药物治疗感到满意。大多数使用药物的一半天的一个月。尽管OA治疗的药物治疗存在一些广泛的差异，但OA对健康状况和工作效率的影响是巨大的，并且在欧洲主要国家之间看起来基本相似。
Objectives. The aims of this study were to examine the impact of peripheral joint OA across five large European countries and how people with OA use pharmacotherapies.Methods. People with self-reported peripheral joint OA were selected from the 2011 five European countries (5EU) National Health and Wellness Survey (NHWS), which included 57 512 respondents from France, Germany, Italy, Spain and the UK. Information was recorded on symptoms, health status, health care utilization, work productivity and medication usage. All variables were analysed descriptively for the total population and individual countries.Results. A total of 3750 respondents met the inclusion criteria: 1635 (43.6%) UK, 961 (25.6%) France, 570 (15.2%) Germany, 316 (8.4%) Spain and 268 (7.1%) Italy. The majority were ages 55-74 years and most were overweight or obese. Health status [12-item Short Form version 2 (SF12v2)] was similar across all countries, with a mean (s.d.) of 40.53 (10.99); 21.5% self-reported experiencing depression. Most had visited a health care provider in the previous 6 months (n = 3537; 94.3%). One third were employed: 7% reported absenteeism and 24% presenteeism. The use of prescription medication for OA was reported by 46.9% of patients, over-the-counter (OTC) medication by 26.5%, and both by 9.4%. Medication use increased with pain severity. NSAIDs were the most commonly used medication. Opioid use varied from 1.8% in Italy to 54.5% in France. Fifty per cent reported full adherence (4-point Morisky Medication Adherence Scale), but only 30% reported satisfaction with their OA medication. Most used medication for half the days of the month.Conclusion. Despite some wide variations in pharmacotherapy for OA treatment, the impact of OA on health status and work productivity is substantial and looks largely similar across major European countries.