Cold exposure increases adiponectin levels in men
Cold exposure increases adiponectin levels in men
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DOI：
10.1016/j.metabol.2008.11.017
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发表时间：
2009-04-01
影响因子：
9.8
通讯作者：
Haman, Francois
中科院分区：
文献类型：
--
作者：
Imbeault, Pascal;Depault, Isabelle;Haman, Francois
在冷暴露期间，在脂肪组织水平上识别交感神经激活。脂联素是由脂肪组织产生的一种关键蛋白质，但其在人体暴露于寒冷中的急性调节仍然未知。本研究的目的是（1）检查冷暴露对循环脂联素的急性影响和（2）确定这些变化是否受到（a）急性葡萄糖摄入以及（B）碳水化合物（CHO）可用性的短期调节的调节。使用随机交叉设计，6名健康男性暴露于寒冷120分钟，在实验过程中摄入含有低（对照，0.04 g/min）或高（高，0.8 g/min）量葡萄糖的饮料（研究1）。研究2：6名健康男性在低胆固醇饮食和运动及高胆固醇饮食不运动后，两次暴露于寒冷中120分钟。在冷暴露之前和期间定量血浆脂联素浓度。在研究1中，脂联素水平在高水平期间没有变化，而在对照期间观察到20%的升高（条件x时间相互作用，P = 0.06）。在研究2中，在低和高CHO饮食后的冷暴露期间，脂联素水平增加约70%（时间效应，P <0.05）。120分钟的寒冷暴露伴随着年轻健康男性脂联素水平的显著增加。在寒战期间观察到的脂联素水平的升高被葡萄糖摄入抑制，但在CHO含量变化的饮食后不受抑制。(C)2009 Elsevier Inc. All rights reserved.
Sympathetic nerve activation is recognized at the adipose tissue level during cold exposure. Adiponectin is a key protein produced by adipose tissue, but its acute modulation remains unknown in humans exposed to cold. The aim of this study were (I) to examine the acute effects of cold exposure on circulating adiponectin and (2) to determine whether the changes are modulated by (a) an acute glucose ingestion as well as (b) a short-term modulation in carbohydrate (CHO) availability. Using a random crossover design, 6 healthy men were exposed to cold for 120 minutes with ingestion of beverages containing low (Control, 0.04 g/min) or high (High, 0.8 g/min) amounts of glucose during the course of the experiment (study 1). In study 2, 6 healthy men were exposed twice to cold for 120 minutes after equicaloric low-CHO diet and exercise and high-CHO diet without exercise. Plasma adiponectin concentrations were quantified before and during cold exposure. In study 1, adiponcctin levels did not change during High, whereas a 20% rise was observed during Control (condition x time interaction, P = .06). In study 2, adiponectin levels increased by approximately 70% during cold exposure after both low- and high-CHO diets (effect of time, P < .05). A 120-minute period of cold exposure is accompanied by a significant increase in adiponectin levels in young healthy men. The rise in adiponectin levels observed during shivering is inhibited with glucose ingestion but not after diets varying in CHO content. (C) 2009 Elsevier Inc. All rights reserved.