Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara
Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara
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Dysideanones A-C，来自南海海绵的不寻常倍半萜醌 Dysidea avara
DOI：
10.1021/np4009392
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发表时间：
2014-02-01
影响因子：
5.1
通讯作者：
Lin, Hou-Wen
中科院分区：
文献类型：
--
作者：
Jiao, Wei-Hua;Xu, Ting-Ting;Lin, Hou-Wen
Dysideanones A-C（1-3）是从中国南海海绵Dysidea avara中分离得到的三种具有碳骨架的倍半萜醌类化合物。通过光谱分析和计算的ECD谱确定了它们的结构，包括绝对构型。在倍半萜醌结构中，dysideanone A（1）和B（2）共享前所未有的6/6/6/6-稠合四环碳骨架，而dysideanone C（3）具有不寻常的6/6/5/6-稠合四环核心。Dysideanone B（2）对两种化合物均表现出细胞毒性。人癌细胞系HeLa和HepG 2，IC 50值分别为7.1和9.4 μ M。
Dysideanones A-C (1-3), three unusual sesquiterpene quinones with unprecedented carbon skeletons, were isolated from the South China Sea sponge Dysidea avara. Their structures including absolute configurations were determined by a combination of spectroscopic analyses and calculated ECD spectra. Within the sesquiterpene quinone structures, dysideanones A (1) and B (2) share an unprecedented 6/6/6/6-fused tetracyclic carbon skeleton, while dysideanone C (3) possesses an unusual 6/6/5/6-fused tetracyclic core. Dysideanone B (2) showed cytotoxicity against two. human cancer cell lines, HeLa and HepG2, with IC50 values of 7.1 and 9.4 mu M, respectively.