The influence of dietary calcium and phosphorus on intestinal calcium transport in rats given vitamin D metabolites.
The influence of dietary calcium and phosphorus on intestinal calcium transport in rats given vitamin D metabolites.
复制标题
膳食钙和磷对给予维生素 D 代谢物的大鼠肠道钙转运的影响。
DOI：
10.1016/0003-9861(75)90148-4
复制
发表时间：
1975
影响因子：
3.9
通讯作者：
H. F. DeLuca
中科院分区：
文献类型：
--
作者：
M. Ribovich;H. F. DeLuca
在服用维生素D3、25-羟基维生素D3或1，25-二羟基维生素D3的大鼠中，比较了低钙饮食和低磷饮食对肠道钙转运的刺激作用。服用1，25-二羟基维生素D3可消除低钙饮食的影响，但不能消除低磷饮食的影响。每天服用大剂量维生素D3或25-羟基维生素D3也可以消除低钙饮食的刺激作用，但不能消除低磷饮食的刺激作用。这些结果表明，除了刺激1，25-二羟基维生素D3的合成外，低磷饮食对肠道钙转运肯定还有其他未知的影响。然而，这些数据与低饮食钙刺激肠道钙转运是1，25-二羟基维生素D3合成增加的直接结果的观点是一致的。
The stimulation of intestinal calcium transport by a low calcium diet has been compared to that produced by a low phosphorus diet in rats given vitamin D3, 25-hydroxyvitamin D3or 1,25-dihydroxyvitamin D3. The administration of 1,25-dihydroxyvitamin D3eliminates the effect of low calcium diets but does not eliminate the effect of low phosphorus diets. The daily administration of large doses of vitamin D3or 25-hydroxyvitamin D3also eliminates the stimulation by low calcium diets but does not eliminate the stimulation by low phosphorus diets. These results suggest that in addition to stimulating 1,25-dihydroxyvitamin D3synthesis, low phosphorus diets must have some other unknown effect on intestinal calcium transport. The data are, however, consistent with the idea that the stimulation of intestinal calcium transport by low dietary calcium is the direct consequence of increased 1,25-dihydroxyvitamin D3synthesis.