Early eyelid opening enhances spontaneous alternation and accelerates the development of perforant path synaptic strength in the hippocampus of juvenile rats
Early eyelid opening enhances spontaneous alternation and accelerates the development of perforant path synaptic strength in the hippocampus of juvenile rats
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DOI：
10.1002/dev.20011
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发表时间：
2004-07-01
影响因子：
2.2
通讯作者：
Dumas, TC
中科院分区：
文献类型：
--
作者：
Dumas, TC
海马体的发育并非完全是预先设定好的；其结构和功能对出生后的经历敏感。例如，新生期的处置/接触新事物以及青春期前后环境的丰富化会增强海马体功能及相关的记忆能力。然而，这些复杂的环境操作使得难以推断出促使海马体更快成熟的主要刺激因素，而且很少有实验研究支持行为改变的神经机制。为了解决这些问题，我对幼鼠进行了早期眼睑睁开操作，并检测了Y型迷宫探索行为以及海马脑片突触传递方面的发育变化。早期眼睑睁开加速了自发交替行为的发展。此外，早期眼睑睁开促进了齿状回和CA1区传入输入的更快重塑，以及穿通纤维通路突触生理学的更早成熟。这些发现表明视觉输入是一种驱动海马体发育以及海马体依赖性行为出现的外在因素。（C）2004威利期刊公司
Development of the hippocampus is not entirely preprogrammed; its structure and function are sensitive to postnatal experience. For instance, neonatal handling/exposure to novelty and peripubertal environmental enrichment enhance hippocampal function and related memory abilities. However these complex environmental manipulations make it difficult to deduce the primary stimuli that drive more rapid hippocampal maturation, and few experiments have studied the neural mechanisms that support the behavioral modifications. To address these issues, I performed early eyelid opening in rat pups and examined developmental alterations in exploration of a Y-maze and in synaptic transmission measured in hippocampal slices. Early eyelid opening accelerated development of spontaneous alternation. Additionally, early eyelid opening promoted more rapid remodeling of afferent input to the dentate gyrus and area CA1 as well as earlier maturation of perforant path synaptic physiology. These findings implicate visual input as an extrinsic factor that drives hippocampal development and the emergence of hippocampal-dependent behavior. (C) 2004 Wiley Periodicals, Inc.