Hippocampal CA1 spiking during encoding and retrieval: Relation to theta phase
Hippocampal CA1 spiking during encoding and retrieval: Relation to theta phase
复制标题
DOI：
10.1016/j.nlm.2006.05.007
复制
发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Eichenbaum, Howard
中科院分区：
文献类型：
--
作者：
Manns, Joseph R.;Zilli, Eric A.;Eichenbaum, Howard
海马θ节律是当大鼠研究环境中的刺激时在整个海马体中观察到的场电位的显着振荡。最近的计算模型 [Hasselmo, M. E., Bodelon, C., & Wyble, B. P. (2002a)。海马θ节律的拟议功能：编码和检索的单独阶段增强了先前学习的逆转。神经计算，14, 793-817。神经调节、θ 节律和大鼠空间导航。 Neural Networks, 15, 689-707] 表明，theta 节律允许海马结构在促进记忆编码的条件（从内嗅皮层到 CA3 和 CA 区域的强突触输入）和促进记忆检索的条件（从 CA3 到 CA1 的强突触输入）之间快速交替。该模型预测，对于正在编码的信息和正在检索的信息，CA1 尖峰的首选 θ 相应该有所不同。在本研究中，当大鼠进行气味提示的延迟不匹配样本识别记忆测试或基于动物对新奇事物的自发偏好的物体识别记忆任务时，记录了CA1锥体细胞的尖峰活动。在这两项任务的测试期间，当大鼠检查重复（匹配）和非重复（不匹配）项目时，CA1 锥体细胞表现出的首选 θ 相有所不同。此外，在本研究中，额外的建模工作扩展了先前的模型，以解决与刺激相关的 CA1 峰值的平均阶段，这些刺激诱导相对于编码的不同检索水平，范围从没有检索的新颖的不匹配刺激到具有广泛检索的高度熟悉的重复刺激。这里获得的建模结果表明，实验观察到的相位差与重复项目识别过程中 CA3 突触输入到 CA1 的不同水平一致。 (c) 2006 Elsevier Inc. 保留所有权利。
The hippocampal theta rhythm is a prominent oscillation in the field potential observed throughout the hippocampus as a rat investigates stimuli in the environment. A recent computational model [Hasselmo, M. E., Bodelon, C., & Wyble, B. P. (2002a). A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning. Neural Computation, 14, 793-817. Neuromodulation, theta rhythm and rat spatial navigation. Neural Networks, 15, 689-707] suggested that the theta rhythm allows the hippocampal formation to alternate rapidly between conditions that promote memory encoding (strong synaptic input from entorhinal cortex to areas CA3 and CA) and conditions that promote memory retrieval (strong synaptic input from CA3 to CA1). That model predicted that the preferred theta phase of CA1 spiking should differ for information being encoded versus information being retrieved. In the present study, the spiking activity of CA1 pyramidal cells was recorded while rats performed either an odor-cued delayed nonmatch-to-sample recognition memory test or an object recognition memory task based on the animal's spontaneous preference for novelty. In the test period of both tasks, the preferred theta phase exhibited by CA1 pyramidal cells differed between moments when the rat inspected repeated (match) and non-repeated (nonmatch) items. Also in the present study, additional modeling work extended the previous model to address the mean phase of CA1 spiking associated with stimuli inducing varying levels of retrieval relative to encoding, ranging from novel nonmatch stimuli with no retrieval to highly familiar repeated stimuli with extensive retrieval. The modeling results obtained here demonstrated that the experimentally observed phase differences are consistent with different levels of CA3 synaptic input to CA1 during recognition of repeated items. (c) 2006 Elsevier Inc. All rights reserved.