The PI3′ kinase pathway in interferon signaling
The PI3′ kinase pathway in interferon signaling
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DOI：
10.1089/jir.2005.25.780
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发表时间：
2005-12-01
影响因子：
2.3
通讯作者：
Platanias, LC
中科院分区：
文献类型：
--
作者：
Kaur, S;Uddin, S;Platanias, LC
干扰素（ifn）是一种多效细胞因子，具有重要的免疫调节、抗肿瘤、抗病毒和生长抑制特性。与其作用的多样性相一致，ifn在与受体结合后激活了几个细胞级联反应。虽然Jak-Stat通路是研究最多的通路，但似乎还有其他信号级联在IFN信号传导中发挥作用。磷脂酰肌醇3'-激酶（PI3'K）途径已成为IFN信号转导的关键参与者之一，是本综述的重点。该通路的激活与Stat通路不同，但在ifn依赖性基因转录和mRNA翻译起始的调控中发挥重要作用。
Interferons (IFNs) are pleiotropic cytokines with important immunomodulatory, antitumor, antiviral, and growth inhibitory properties. Consistent with the multiplicity of their effects, the IFNs activate several cellular cascades after they bind to their receptors. Although the Jak-Stat pathway is the most studied pathway, it appears that additional signaling cascades play roles in IFN signaling. The phosphatidylinositol 3'-kinase (PI3'K) pathway has emerged as one of the critical players in IFN signal transduction and is the focus of this review. This pathway is activated distinctively from the Stat pathway but plays important roles in the regulation of IFN-dependent gene transcription and initiation of mRNA translation.