Influenza B virus in seals
Influenza B virus in seals
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DOI：
10.1126/science.288.5468.1051
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发表时间：
2000-05-12
期刊：
影响因子：
56.9
通讯作者：
Fouchier, RAM
中科院分区：
文献类型：
--
作者：
Osterhaus, ADME;Rimmelzwaan, GF;Fouchier, RAM
乙型流感病毒是一种人类病原体，其起源和在自然界中可能的宿主尚不清楚。从自然感染的斑海豹（Phoca vitulina）中分离出一种乙型流感病毒，并在体外发现该病毒对封闭肾细胞具有传染性。序列分析和血清学分析表明，流感病毒B/Seal/Netherlands/1/99与4至5年前在人类中传播的毒株密切相关。对971只海豹采集的血清进行回顾性分析，结果显示1995年以后2%的动物存在乙型流感病毒抗体，1995年以前没有。这一动物宿主窝藏过去传播过的乙型流感病毒，可能对人类构成直接威胁。
Influenza B virus is a human pathogen whose origin and possible reservoir in nature are not known. An influenza B virus was isolated from a naturally infected harbor seal (Phoca vitulina) and was found to be infectious to seal kidney cells in vitro. Sequence analyses and serology indicated that influenza virus B/Seal/Netherlands/1/99 is closely related to strains that circulated in humans 4 to 5 years earlier. Retrospective analyses of sera collected from 971 seals showed a prevalence of antibodies to influenza B virus in 2% of the animals after 1995 and in none before 1995. This animal reservoir, harboring influenza B viruses that have circulated in the past, may pose a direct threat to humans.