Introduction to the Special Issue on Statistical Genetic Methods for Human Complex Traits.
Introduction to the Special Issue on Statistical Genetic Methods for Human Complex Traits.
复制标题
人类复杂性状统计遗传方法特刊简介。
DOI：
10.1007/s10519-021-10057-9
复制
发表时间：
2021
影响因子：
2.6
通讯作者：
Prom-Wormley,Elizabeth
中科院分区：
文献类型：
--
作者：
Evans,DavidM;Medland,SarahE;Prom-Wormley,Elizabeth
It is now just over 30 years since the International Statistical Genetics Workshop (commonly referred to as “The Boulder Workshop” or just “The Workshop”) found a home in Boulder Colorado. 1 The early years of The Workshop focused predominantly on the analysis of twin data via structural equation modelling-first using the LISREL software package (Joreskog and Sorbom 1981) and subsequently using Mike Neale’s Mx program (Neale 2006). Two special issues, published in Behavior Genetics in 1989 and 1993, contain manuscripts describing some of the models and methods taught at these initial, and as it turned out, later workshops. Indeed, several of these articles became citation classics, and many of the methods described within them, still represent the orthodox approach to analyzing twin and family data today.The content of the workshop has changed markedly over the years in response to the widespread availability of molecular genetics data. Initially, content addressed the advent of microsatellite panels. More recently, the programme has expanded to include genome-wide SNP arrays and sequencing data. Linkage and candidate gene association analyses were incorporated into the curriculum in the late 1990s and early 2000s, followed by genome-wide association (Wellcome Trust Case Control 2007), G-REML (Yang et al. 2011) and Mendelian randomization approaches (Smith and Ebrahim 2003), and most recently LD score regression
