High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: A report from the ADHERE database
High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: A report from the ADHERE database
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DOI：
10.1016/j.cardfail.2007.03.011
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发表时间：
2007-08-01
影响因子：
6
通讯作者：
Wynne, Janet
中科院分区：
文献类型：
--
作者：
Heywood, J. Thomas;Fonarow, Gregg C.;Wynne, Janet
背景：急性失代偿性心力衰竭住院患者肾功能不全的患病率仍不清楚。方法和结果：对118,465例住院事件的数据进行评估。肾小球滤过率（GFR）采用肾脏疾病简化饮食修正公式估算，入院时，10,660例（9.0%）患者肾功能正常（GFR >= 90 mL.min.1.73 m(2)）， 32,423例（27.4%）患者轻度肾功能不全（GFR 60-89 mL.min.1.73 m(2)）， 51,553例（43.5%）患者中度肾功能不全（GFR 30-59 mL.min.1.73 m(2)）， 15,553例（13.1%）患者重度肾功能不全（GFR 15-29 mL.min.1.73 m(2)）。8276例（7.0%）发生肾衰竭（GFR < 15 mL.min.1.73 m(2)或慢性透析）。尽管如此，只有33.4%的男性和27.3%的女性被诊断为肾功能不全。利尿剂、肌力药物和奈西立肽的使用增加，而血管紧张素转换酶抑制剂或血管紧张素11受体阻滞剂的使用减少，肾功能不全增加
Background: The prevalence of renal dysfunction in patients hospitalized with acute decompensated heart failure remains poorly characterized.Methods and Results: Data from 118,465 hospitalization episodes were evaluated. Glomerular filtration rate (GFR) was estimated using the abbreviated Modification of Diet in Renal Disease formula, At admission, 10,660 patients (9.0%) had normal renal function (GFR >= 90 mL.min.1.73 m(2)), 32,423 patients (27.4%) had mild renal dysfunction (GFR 60-89 mL.min.1.73 m(2)) 51,553 patients (43.5%) had moderate renal dysfunction (GFR 30-59 mL.min.1.73 m(2)), 15,553 patients (13.1%) had severe renal dysfunction (GFR 15-29 mL.min.1.73 m(2)), and 8276 patients (7.0%) had kidney failure (GFR < 15 mL.min.1.73 m(2) or chronic dialysis). Despite this, only 33.4% of men and 27.3% of women were diagnosed with renal insufficiency. Diuretic dose, inotrope use, and nesiritide use increased, whereas angiotensin-converting enzyme inhibitor or angiotensin 11 receptor blocker use decreased, with increasing renal dysfunction (all P