Preference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonism
Preference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonism
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DOI：
10.1097/fbp.0000000000000556
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发表时间：
2020-09-01
影响因子：
1.6
通讯作者：
Salamone, John D.
中科院分区：
文献类型：
--
作者：
Correa, Merce;Pardo, Marta;Salamone, John D.
动机有激励性和方向性两个部分。中脑边缘多巴胺对动机行为中的行为激活和努力相关过程的调节至关重要。损害中脑边缘多巴胺功能会导致疲劳和无痛，但不会影响寻求强化行为的其他方面，如消耗性或享乐性成分。在雄性瑞士小鼠中，我们表征了多巴胺拮抗对同时呈现的具有不同活力要求的刺激的选择的影响。我们分析了跑轮活动与蔗糖溶液摄入量之间的关系，蔗糖溶液的摄入量通常被用作快感缺失的衡量标准。结果与对这些刺激的非同时呈现的数据进行比较。在同时呈现实验中，与蔗糖摄入相比，对照组小鼠更喜欢花时间跑步。多巴胺拮抗改变了相对强化剂的偏好，减少了在跑轮上花费的时间，但实际上增加了耗时的蔗糖。老鼠增加了两种增强剂的发作频率，这表明跑轮中存在疲劳，而不是厌恶。此外，让动物预先接触两种强化剂的饱腹感或习惯性并不会改变他们的喜好。在非同时实验中，氟哌啶醇减少了跑轮，但对蔗糖消耗没有影响。多巴胺拮抗不会改变对蔗糖或总摄入量的偏好。额外的相关分析表明，蔗糖消耗的基线差异与基线跑步或新奇探索无关。因此，多巴胺拮抗似乎有无能而不是无快感的影响，在这种情况下同时呈现可能有助于评估基于努力要求的偏好。
Motivation has activational and directional components. Mesolimbic dopamine is critical for the regulation of behavioral activation and effort-related processes in motivated behaviors. Impairing mesolimbic dopamine function leads to fatigue and anergia, but leaves intact other aspects of reinforce seeking behaviors, such as the consummatory or hedonic component. In male Swiss mice, we characterized the impact of dopamine antagonism on the selection of concurrently presented stimuli that have different vigor requirements. We analyzed running wheel activity versus sucrose solution intake, typically used as a measure of anhedonia. Results are compared with data from nonconcurrent presentation to those stimuli. In the concurrent presentation experiment, control mice preferred to spend time running compared to sucrose intake. Dopamine antagonism shifted relative reinforcer preference, reducing time spent on the running wheel, but actually increasing time-consuming sucrose. Mice increased frequency of bouts for both reinforcers, suggesting that there was fatigue in the running wheel rather than aversion. Moreover, satiation or habituation by preexposing animals to both reinforcers did not shift preferences. In the nonconcurrent experiments, haloperidol reduced running wheel but had no impact on sucrose consumption. Dopamine antagonism did not change preference for sucrose or total volume consumed. Additional correlational analyses indicated that baseline differences in sucrose consumption were independent of baseline running or novelty exploration. Thus, dopamine antagonism seems to have anergic rather than anhedonic effects, and the concurrent presentation in this setting could be useful for assessing preferences based on effort requirements.