Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis
Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis
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DOI：
10.1164/rccm.200211-1311oc
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发表时间：
2003-09-01
影响因子：
24.7
通讯作者：
Brown, KK
中科院分区：
文献类型：
--
作者：
Collard, HR;King, TE;Brown, KK
特发性肺纤维化患者的生存时间存在显着的异质性。将基线临床和生理变量作为生存时间预测因子的研究报告了不一致的结果。我们评估了 81 名经活检证实患有特发性肺纤维化的患者的临床和生理变量随时间变化对生存时间的预测价值。即使在调整基线值后，呼吸困难评分、肺总量、胸腔气体容量、FVC、FEV1、一氧化碳弥散能力、动脉氧分压、氧饱和度和肺泡动脉氧梯度的六个月变化也可以预测生存时间。对 51 名患者的 12 个月变化数据进行了重复分析。呼吸困难评分、总肺活量、FVC、动脉氧分压、氧饱和度和肺泡动脉氧梯度的 12 个月变化可预测调整基线值后的生存时间。对 6 个月和 12 个月内临床和生理变量变化的评估可以为临床医生提供比单独基线值更准确的预后信息。
There is significant heterogeneity in survival time among patients with idiopathic pulmonary fibrosis. Studies of baseline clinical and physiologic variables as predictors of survival time have reported inconsistent results. We evaluated the predictive value of changes in clinical and physiologic variables over time for survival time in 81 patients with biopsy-proven idiopathic pulmonary fibrosis. Six-month changes in dyspnea score, total lung capacity, thoracic gas volume, FVC, FEV1, diffusing capacity of carbon monoxide, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time even after adjustment for baseline values. Analyses were repeated on 51 patients with 12-month change data. Twelve-month changes in dyspnea score, total lung capacity, FVC, partial pressure of arterial oxygen, oxygen saturation, and alveolar-arterial oxygen gradient were predictive of survival time after adjustment for baseline values. Evaluation of changes in clinical and physiological variables over 6 and 12 months may provide clinicians with more accurate prognostic information than baseline values alone.